Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood

Celedón, JC; Milton, DK; Ramsey, CD; Litonjua, AA; Ryan, L; Platts-Mills, TAE; Gold, DR

Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood

Celedón, JC Milton, DK Ramsey, CD Litonjua, AA Ryan, L

Platts-Mills, TAE Gold, DR

Permalink

Publication Type:: Journal Article
Citation:: Journal of Allergy and Clinical Immunology, 2007, 120 (1), pp. 144 - 149
Issue Date:: 2007-07-01

Closed Access

	Filename	Description	Size
	2011008530OK.pdf		123.18 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Celedón, JC	en_US
dc.contributor.author	Milton, DK	en_US
dc.contributor.author	Ramsey, CD	en_US
dc.contributor.author	Litonjua, AA	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Platts-Mills, TAE	en_US
dc.contributor.author	Gold, DR	en_US
dc.date.available	2007-03-27	en_US
dc.date.issued	2007-07-01	en_US
dc.identifier.citation	Journal of Allergy and Clinical Immunology, 2007, 120 (1), pp. 144 - 149	en_US
dc.identifier.issn	0091-6749	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26011
dc.description.abstract	Background: There has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age. Objectives: To examine the relation between exposure to dust mite allergen and endotoxin at age 2 to 3 months and asthma, wheeze, and atopy in high-risk children. Methods: Birth cohort study of 440 children with parental history of atopy in the Boston metropolitan area. Results: In multivariate analyses, early exposure to high levels of dust mite allergen (≥10 μg/g) was associated with increased risks of asthma at age 7 years (odds ratio [OR], 3.0; 95% CI, 1.1-7.9) and late-onset wheeze (OR, 5.0; 95% CI, 1.5-16.4). Exposure to endotoxin levels above the lowest quartile at age 2 to 3 months was associated with reduced odds of atopy at school age (OR, 0.5; 95% CI, 0.2-0.9). In contrast with its inverse association with atopy, endotoxin exposure in early life was associated with an increased risk of any wheeze between ages 1 and 7 years that did not change significantly with time (hazard ratio for each quartile increment in endotoxin levels, 1.23; 95% CI, 1.07-1.43). Conclusion: Among children at risk of atopy, early exposure to high levels of dust mite allergen is associated with increased risks of asthma and late-onset wheeze. In these children, endotoxin exposure is associated with a reduced risk of atopy but an increased risk of wheeze. Clinical implications: Early endotoxin exposure may be a protective factor against atopy but a risk factor for wheeze in high-risk children. © 2007 American Academy of Allergy, Asthma & Immunology.	en_US
dc.relation.ispartof	Journal of Allergy and Clinical Immunology	en_US
dc.relation.isbasedon	10.1016/j.jaci.2007.03.037	en_US
dc.subject.classification	Allergy	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Hypersensitivity, Immediate	en_US
dc.subject.mesh	Endotoxins	en_US
dc.subject.mesh	Antigens, Dermatophagoides	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Environmental Exposure	en_US
dc.subject.mesh	Child	en_US
dc.subject.mesh	Infant	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	120	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	120	en_US

Abstract:

Background: There has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age. Objectives: To examine the relation between exposure to dust mite allergen and endotoxin at age 2 to 3 months and asthma, wheeze, and atopy in high-risk children. Methods: Birth cohort study of 440 children with parental history of atopy in the Boston metropolitan area. Results: In multivariate analyses, early exposure to high levels of dust mite allergen (≥10 μg/g) was associated with increased risks of asthma at age 7 years (odds ratio [OR], 3.0; 95% CI, 1.1-7.9) and late-onset wheeze (OR, 5.0; 95% CI, 1.5-16.4). Exposure to endotoxin levels above the lowest quartile at age 2 to 3 months was associated with reduced odds of atopy at school age (OR, 0.5; 95% CI, 0.2-0.9). In contrast with its inverse association with atopy, endotoxin exposure in early life was associated with an increased risk of any wheeze between ages 1 and 7 years that did not change significantly with time (hazard ratio for each quartile increment in endotoxin levels, 1.23; 95% CI, 1.07-1.43). Conclusion: Among children at risk of atopy, early exposure to high levels of dust mite allergen is associated with increased risks of asthma and late-onset wheeze. In these children, endotoxin exposure is associated with a reduced risk of atopy but an increased risk of wheeze. Clinical implications: Early endotoxin exposure may be a protective factor against atopy but a risk factor for wheeze in high-risk children. © 2007 American Academy of Allergy, Asthma & Immunology.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/26011