A case-control study of GST polymorphisms and arsenic related skin lesions

McCarty, KM; Ryan, L; Houseman, EA; Williams, PL; Miller, DP; Quamruzzaman, Q; Rahman, M; Mahiuddin, G; Smith, T; Gonzalez, E; Su, L; Christiani, DC

A case-control study of GST polymorphisms and arsenic related skin lesions

McCarty, KM Ryan, L

Houseman, EA Williams, PL Miller, DP Quamruzzaman, Q Rahman, M Mahiuddin, G Smith, T Gonzalez, E Su, L Christiani, DC

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Publication Type:: Journal Article
Citation:: Environmental Health: A Global Access Science Source, 2007, 6
Issue Date:: 2007-03-06

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Field	Value	Language
dc.contributor.author	McCarty, KM	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Houseman, EA	en_US
dc.contributor.author	Williams, PL	en_US
dc.contributor.author	Miller, DP	en_US
dc.contributor.author	Quamruzzaman, Q	en_US
dc.contributor.author	Rahman, M	en_US
dc.contributor.author	Mahiuddin, G	en_US
dc.contributor.author	Smith, T	en_US
dc.contributor.author	Gonzalez, E	en_US
dc.contributor.author	Su, L	en_US
dc.contributor.author	Christiani, DC	en_US
dc.date.available	2007-02-06	en_US
dc.date.issued	2007-03-06	en_US
dc.identifier.citation	Environmental Health: A Global Access Science Source, 2007, 6	en_US
dc.identifier.uri	http://hdl.handle.net/10453/88306
dc.description.abstract	Background. Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH conjugates. Methods. We investigated whether polymorphisms in GSTT1, GSTP1 and GSTM1 were associated with risk of skin lesions and whether these polymorphisms modify the relationship between drinking water arsenic exposure and skin lesions in a case control study of 1200 subjects frequency matched on age and gender in community clinics in Pabna, Bangladesh in 2001-2002. Results and discussion. GSTT1 homozygous wildtype status was associated with increased odds of skin lesions compared to the null status (OR1.56 95% CI 1.10-2.19). The GSTP1 GG polymorphism was associated with greater odds of skin lesions compared to GSTP1 AA, (OR 1.86 (95%CI 1.15-3.00). No evidence of effect modification by GSTT1, GSTM1 or GSTP1 polymorphisms on the association between arsenic exposure and skin lesions was detected. Conclusion. GSTT1 wildtype and GSTP1 GG are associated with increased risk of skin lesions. © 2007 McCarty et al; licensee BioMed Central Ltd.	en_US
dc.relation.ispartof	Environmental Health: A Global Access Science Source	en_US
dc.relation.isbasedon	10.1186/1476-069X-6-5	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Skin Neoplasms	en_US
dc.subject.mesh	Arsenic Poisoning	en_US
dc.subject.mesh	Arsenic	en_US
dc.subject.mesh	Glutathione Transferase	en_US
dc.subject.mesh	Odds Ratio	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Regression Analysis	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Causality	en_US
dc.subject.mesh	Water Supply	en_US
dc.subject.mesh	Genotype	en_US
dc.subject.mesh	Polymorphism, Genetic	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	India	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Glutathione S-Transferase pi	en_US
dc.title	A case-control study of GST polymorphisms and arsenic related skin lesions	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

Background. Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH conjugates. Methods. We investigated whether polymorphisms in GSTT1, GSTP1 and GSTM1 were associated with risk of skin lesions and whether these polymorphisms modify the relationship between drinking water arsenic exposure and skin lesions in a case control study of 1200 subjects frequency matched on age and gender in community clinics in Pabna, Bangladesh in 2001-2002. Results and discussion. GSTT1 homozygous wildtype status was associated with increased odds of skin lesions compared to the null status (OR1.56 95% CI 1.10-2.19). The GSTP1 GG polymorphism was associated with greater odds of skin lesions compared to GSTP1 AA, (OR 1.86 (95%CI 1.15-3.00). No evidence of effect modification by GSTT1, GSTM1 or GSTP1 polymorphisms on the association between arsenic exposure and skin lesions was detected. Conclusion. GSTT1 wildtype and GSTP1 GG are associated with increased risk of skin lesions. © 2007 McCarty et al; licensee BioMed Central Ltd.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/26013