Fungal levels in the home and allergic rhinitis by 5 years of age

Stark, PC; Celedón, JC; Chew, GL; Ryan, LM; Burge, HA; Muilenberg, ML; Gold, DR

Fungal levels in the home and allergic rhinitis by 5 years of age

Stark, PC Celedón, JC Chew, GL Ryan, LM

Burge, HA Muilenberg, ML Gold, DR

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Publication Type:: Journal Article
Citation:: Environmental Health Perspectives, 2005, 113 (10), pp. 1405 - 1409
Issue Date:: 2005-10-01

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Field	Value	Language
dc.contributor.author	Stark, PC	en_US
dc.contributor.author	Celedón, JC	en_US
dc.contributor.author	Chew, GL	en_US
dc.contributor.author	Ryan, LM https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Burge, HA	en_US
dc.contributor.author	Muilenberg, ML	en_US
dc.contributor.author	Gold, DR	en_US
dc.date.issued	2005-10-01	en_US
dc.identifier.citation	Environmental Health Perspectives, 2005, 113 (10), pp. 1405 - 1409	en_US
dc.identifier.issn	0091-6765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26022
dc.description.abstract	Studies have repeatedly demonstrated that sensitization to fungi, such as Alternaria, is strongly associated with allergic rhinitis and asthma in children. However, the role of exposure to fungi in the development of childhood allergic rhinitis is poorly understood. In a prospective birth cohort of 405 children of asthmatic/allergic parents from metropolitan Boston, Massachusetts, we examined in-home high fungal concentrations (> 90th percentile) measured once within the first 3 months of life as predictors of doctor-diagnosed allergic rhinitis in the first 5 years of life. In multivariate Cox regression analyses, predictors of allergic rhinitis included high levels of dust-borne Aspergillus [hazard ratio (HR) = 3.27; 95% confidence interval (CI), 1.50-7.14], Aureobasidium (HR = 3.04; 95% CI, 1.33-6.93), and yeasts (HR = 2.67; 95% CI, 1.26-5.66). The factors controlled for in these analyses included water damage or mild or mildew in the building during the first year of the child's life, any lower respiratory tract infection in the first year, male sex, African-American race, fall date of birth, and maternal IgE to Alternaria > 0.35 U/mL. Dust-borne Alternaria and nonsporulating and total fungi were also predictors of allergic rhinitis in models excluding other fungi but adjusting for all of the potential confounders listed above. High measured fungal concentrations and reports of water damage, mold, or mildew in homes may predispose children with a family history of asthma or allergy to the development of allergic rhinitis.	en_US
dc.relation.ispartof	Environmental Health Perspectives	en_US
dc.relation.isbasedon	10.1289/ehp.7844	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Fungi	en_US
dc.subject.mesh	Rhinitis, Allergic, Perennial	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Child, Preschool	en_US
dc.subject.mesh	Boston	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Fungal levels in the home and allergic rhinitis by 5 years of age	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.citation.volume	113	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	05 Environmental Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	10	en_US
pubs.publication-status	Published	en_US
pubs.volume	113	en_US

Abstract:

Studies have repeatedly demonstrated that sensitization to fungi, such as Alternaria, is strongly associated with allergic rhinitis and asthma in children. However, the role of exposure to fungi in the development of childhood allergic rhinitis is poorly understood. In a prospective birth cohort of 405 children of asthmatic/allergic parents from metropolitan Boston, Massachusetts, we examined in-home high fungal concentrations (> 90th percentile) measured once within the first 3 months of life as predictors of doctor-diagnosed allergic rhinitis in the first 5 years of life. In multivariate Cox regression analyses, predictors of allergic rhinitis included high levels of dust-borne Aspergillus [hazard ratio (HR) = 3.27; 95% confidence interval (CI), 1.50-7.14], Aureobasidium (HR = 3.04; 95% CI, 1.33-6.93), and yeasts (HR = 2.67; 95% CI, 1.26-5.66). The factors controlled for in these analyses included water damage or mild or mildew in the building during the first year of the child's life, any lower respiratory tract infection in the first year, male sex, African-American race, fall date of birth, and maternal IgE to Alternaria > 0.35 U/mL. Dust-borne Alternaria and nonsporulating and total fungi were also predictors of allergic rhinitis in models excluding other fungi but adjusting for all of the potential confounders listed above. High measured fungal concentrations and reports of water damage, mold, or mildew in homes may predispose children with a family history of asthma or allergy to the development of allergic rhinitis.

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http://hdl.handle.net/10453/26022