Joint Modelling Of Survival And Cognitive Decline In The Australian Longitudinal Study Of Ageing

Publisher:
Wiley-blackwell
Publication Type:
Journal Article
Citation:
Journal of the Royal Statistical Society Series C: Applied Statistics, 2011, 60 (2), pp. 221 - 238
Issue Date:
2011-01
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2011008512OK.pdf994.2 kB
Adobe PDF
The paper describes the use of a longitudinal tobit model to characterize cognitive decline over a 13-year period in a cohort of 2087 elderly Australians. Use of a tobit formulation allows for the so-called `ceiling effect wherein many subjects achieve perfect test scores. A Bayesian hierarchical joint model is presented that allows for random subject-specific intercepts and slopes, as well as for informative dropout. Results suggest several potential areas of intervention. For example, there is a clear doseresponse effect of exercise whereby increasing levels of exercise are associated with higher cognitive scores.
Please use this identifier to cite or link to this item: