Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population

Chen, YC; Christiani, DC; Su, HJJ; Hsueh, YM; Smith, TJ; Ryan, LM; Chao, SC; Lee, JYY; Guo, YLL

Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population

Chen, YC Christiani, DC Su, HJJ Hsueh, YM Smith, TJ Ryan, LM

Chao, SC Lee, JYY Guo, YLL

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Publication Type:: Journal Article
Citation:: Cancer Causes and Control, 2010, 21 (5), pp. 771 - 776
Issue Date:: 2010-05-01

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Field	Value	Language
dc.contributor.author	Chen, YC	en_US
dc.contributor.author	Christiani, DC	en_US
dc.contributor.author	Su, HJJ	en_US
dc.contributor.author	Hsueh, YM	en_US
dc.contributor.author	Smith, TJ	en_US
dc.contributor.author	Ryan, LM https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Chao, SC	en_US
dc.contributor.author	Lee, JYY	en_US
dc.contributor.author	Guo, YLL	en_US
dc.date.available	2010-01-06	en_US
dc.date.issued	2010-05-01	en_US
dc.identifier.citation	Cancer Causes and Control, 2010, 21 (5), pp. 771 - 776	en_US
dc.identifier.issn	0957-5243	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26061
dc.description.abstract	Background It has been widely accepted that sun exposure is a risk factor of squamous cell carcinoma (SCC) among fair-skinned populations. However, sun exposure and sun reaction have not been explored in Asians and no gender-specific data were available. Method In a case-control study, 176 incident skin cancer cases were recruited from National Cheng-Kung University Medical Center from 1996 to 1999. Controls included 216 age-, gender-, and residency-matched subjects from the southwestern Taiwan. A questionnaire was administered to collect information on life style and other risk factors. Logistic regression analysis was performed to evaluate the association between sun exposure or sun reaction and the risk of SCC by gender. Results Early-age (age 15 to 24) and lifetime sun exposure were significantly associated with increased risk of SCC in a dose-response pattern [odds ratio (OR) = 1.49-3.08, trend p = 0.009 and 0.0007, respectively]. After stratified by gender, the third tertile of early-age sun exposure was significantly associated with the SCC risk among men (OR = 3.08). The second and third tertiles of lifetime sun exposure was significantly associated with SCC risk among women (OR = 3.78 and 4.53, respectively). Skin reaction after 2-h sun exposure during childhood and adolescence was not significantly associated with the risk of SCC. Conclusions Lifetime sun exposure was more related to SCC risk in women, while early-age sun exposure was more relevant to men's SCC risk. This may be attributable to different lifestyle between men and women. © Springer Science+Business Media B.V. 2010.	en_US
dc.relation.ispartof	Cancer Causes and Control	en_US
dc.relation.isbasedon	10.1007/s10552-010-9505-x	en_US
dc.subject.classification	Epidemiology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Carcinoma, Squamous Cell	en_US
dc.subject.mesh	Skin Neoplasms	en_US
dc.subject.mesh	Sunburn	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Odds Ratio	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Sunlight	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Asian Continental Ancestry Group	en_US
dc.subject.mesh	Taiwan	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	21	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	21	en_US

Abstract:

Background It has been widely accepted that sun exposure is a risk factor of squamous cell carcinoma (SCC) among fair-skinned populations. However, sun exposure and sun reaction have not been explored in Asians and no gender-specific data were available. Method In a case-control study, 176 incident skin cancer cases were recruited from National Cheng-Kung University Medical Center from 1996 to 1999. Controls included 216 age-, gender-, and residency-matched subjects from the southwestern Taiwan. A questionnaire was administered to collect information on life style and other risk factors. Logistic regression analysis was performed to evaluate the association between sun exposure or sun reaction and the risk of SCC by gender. Results Early-age (age 15 to 24) and lifetime sun exposure were significantly associated with increased risk of SCC in a dose-response pattern [odds ratio (OR) = 1.49-3.08, trend p = 0.009 and 0.0007, respectively]. After stratified by gender, the third tertile of early-age sun exposure was significantly associated with the SCC risk among men (OR = 3.08). The second and third tertiles of lifetime sun exposure was significantly associated with SCC risk among women (OR = 3.78 and 4.53, respectively). Skin reaction after 2-h sun exposure during childhood and adolescence was not significantly associated with the risk of SCC. Conclusions Lifetime sun exposure was more related to SCC risk in women, while early-age sun exposure was more relevant to men's SCC risk. This may be attributable to different lifestyle between men and women. © Springer Science+Business Media B.V. 2010.

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http://hdl.handle.net/10453/26061