Variation in total and specific IgE: Effects of ethnicity and socioeconomic status

Litonjua, AA; Celedón, JC; Hausmann, J; Nikolov, M; Sredl, D; Ryan, L; Platts-Mills, TAE; Weiss, ST; Gold, DR

Variation in total and specific IgE: Effects of ethnicity and socioeconomic status

Litonjua, AA Celedón, JC Hausmann, J Nikolov, M Sredl, D Ryan, L

Platts-Mills, TAE Weiss, ST Gold, DR

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Publication Type:: Journal Article
Citation:: Journal of Allergy and Clinical Immunology, 2005, 115 (4), pp. 751 - 757
Issue Date:: 2005-01-01

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Field	Value	Language
dc.contributor.author	Litonjua, AA	en_US
dc.contributor.author	Celedón, JC	en_US
dc.contributor.author	Hausmann, J	en_US
dc.contributor.author	Nikolov, M	en_US
dc.contributor.author	Sredl, D	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Platts-Mills, TAE	en_US
dc.contributor.author	Weiss, ST	en_US
dc.contributor.author	Gold, DR	en_US
dc.date.issued	2005-01-01	en_US
dc.identifier.citation	Journal of Allergy and Clinical Immunology, 2005, 115 (4), pp. 751 - 757	en_US
dc.identifier.issn	0091-6749	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26172
dc.description.abstract	Background: Asthma is common in minority and disadvantaged populations, whereas atopic disorders other than asthma appear to be less prevalent. It is unclear whether the same holds true for objective markers of sensitization. Objective: To determine the association of asthma, atopic disorders, and specific sensitization with race and socioeconomic factors. Methods: We analyzed total and specific IgE among 882 women (577 white, 169 black, and 136 Hispanic) who delivered a child at a large tertiary hospital in Boston, Mass, and who were screened for participation in a family and birth cohort study. Race/ethnicity and other characteristics were obtained from screening questionnaires. Addresses were geocoded, and 3 census-based geographic area socioeconomic variables were derived from block group information from the 1990 US Census. Results: Black and Hispanic women were more likely to come from areas with low socioeconomic indicators and were more likely to have asthma than white women. However, these women were less likely to have hay fever and eczema than their white counterparts. Compared with white women, black women had higher mean total IgE levels; had greater proportions of sensitization to indoor, outdoor, and fungal allergens; and were more than twice as likely to be sensitized to ≥3 aeroallergens. Conclusion: The racial/ethnic disparities in atopic disorders may represent either underdiagnosis or underreporting and suggest that allergy testing may be underused in some populations. Differences in total IgE levels and specific allergen sensitization are likely a result of the complex interplay between exposures associated with socioeconomic disadvantage. © 2005 American Academy of Allergy, Asthma and Immunology.	en_US
dc.relation.ispartof	Journal of Allergy and Clinical Immunology	en_US
dc.relation.isbasedon	10.1016/j.jaci.2004.12.1138	en_US
dc.subject.classification	Allergy	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Hypersensitivity	en_US
dc.subject.mesh	Immunoglobulin E	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Social Class	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Ethnic Groups	en_US
dc.subject.mesh	Female	en_US
dc.title	Variation in total and specific IgE: Effects of ethnicity and socioeconomic status	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	115	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	115	en_US

Abstract:

Background: Asthma is common in minority and disadvantaged populations, whereas atopic disorders other than asthma appear to be less prevalent. It is unclear whether the same holds true for objective markers of sensitization. Objective: To determine the association of asthma, atopic disorders, and specific sensitization with race and socioeconomic factors. Methods: We analyzed total and specific IgE among 882 women (577 white, 169 black, and 136 Hispanic) who delivered a child at a large tertiary hospital in Boston, Mass, and who were screened for participation in a family and birth cohort study. Race/ethnicity and other characteristics were obtained from screening questionnaires. Addresses were geocoded, and 3 census-based geographic area socioeconomic variables were derived from block group information from the 1990 US Census. Results: Black and Hispanic women were more likely to come from areas with low socioeconomic indicators and were more likely to have asthma than white women. However, these women were less likely to have hay fever and eczema than their white counterparts. Compared with white women, black women had higher mean total IgE levels; had greater proportions of sensitization to indoor, outdoor, and fungal allergens; and were more than twice as likely to be sensitized to ≥3 aeroallergens. Conclusion: The racial/ethnic disparities in atopic disorders may represent either underdiagnosis or underreporting and suggest that allergy testing may be underused in some populations. Differences in total IgE levels and specific allergen sensitization are likely a result of the complex interplay between exposures associated with socioeconomic disadvantage. © 2005 American Academy of Allergy, Asthma and Immunology.

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http://hdl.handle.net/10453/26172