Use of historical controls in time-adjusted trend tests for carcinogenicity

Ibrahim, JG; Ryan, LM

Use of historical controls in time-adjusted trend tests for carcinogenicity

Ibrahim, JG Ryan, LM

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Publication Type:: Journal Article
Citation:: Biometrics, 1996, 52 (4), pp. 1478 - 1485
Issue Date:: 1996-12-01

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Field	Value	Language
dc.contributor.author	Ibrahim, JG	en_US
dc.contributor.author	Ryan, LM https://orcid.org/0000-0001-5957-2490	en_US
dc.date.issued	1996-12-01	en_US
dc.identifier.citation	Biometrics, 1996, 52 (4), pp. 1478 - 1485	en_US
dc.identifier.issn	0006-341X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26190
dc.description.abstract	We develop a method for incorporating historical control information into time-adjusted tests for dose effects in carcinogenicity studies. After discretizing the time scale, we use a multinomial distribution to model the number of animals dying with tumor in each interval and specify a Dirichlet prior distribution on the control tumor death rates in each interval. Data from past studies are used to estimate the parameters characterizing the prior. A score test derived from the resulting Dirichlet-multinomial generalizes the test of Tarone (1982, Biometrics 38, 215 220) and reduces, in the limit, to the log-rank test in the case of a diffuse prior. The methodology is illustrated with data from a study of the fire retardant 2,2- Bis(bromomethyl)-1,3-propanediol.	en_US
dc.relation.ispartof	Biometrics	en_US
dc.relation.isbasedon	10.2307/2532862	en_US
dc.subject.classification	Statistics & Probability	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats, Inbred F344	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Mesothelioma	en_US
dc.subject.mesh	Propylene Glycols	en_US
dc.subject.mesh	Flame Retardants	en_US
dc.subject.mesh	Carcinogens	en_US
dc.subject.mesh	Models, Statistical	en_US
dc.subject.mesh	Likelihood Functions	en_US
dc.subject.mesh	Carcinogenicity Tests	en_US
dc.subject.mesh	Biometry	en_US
dc.subject.mesh	Time Factors	en_US
dc.subject.mesh	Male	en_US
dc.title	Use of historical controls in time-adjusted trend tests for carcinogenicity	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	52	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	0104 Statistics	en_US
utslib.for	0199 Other Mathematical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	52	en_US

Abstract:

We develop a method for incorporating historical control information into time-adjusted tests for dose effects in carcinogenicity studies. After discretizing the time scale, we use a multinomial distribution to model the number of animals dying with tumor in each interval and specify a Dirichlet prior distribution on the control tumor death rates in each interval. Data from past studies are used to estimate the parameters characterizing the prior. A score test derived from the resulting Dirichlet-multinomial generalizes the test of Tarone (1982, Biometrics 38, 215 220) and reduces, in the limit, to the log-rank test in the case of a diffuse prior. The methodology is illustrated with data from a study of the fire retardant 2,2- Bis(bromomethyl)-1,3-propanediol.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/26190