Prognostic factors for survival in hepatocellular carcinoma

Publisher:
Amer Assoc Cancer Research
Publication Type:
Journal Article
Citation:
Cancer Research, 1988, 48 (24), pp. 7314 - 7318
Issue Date:
1988-01
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Associations between patient characteristics and survival were inves tigated in 432 patients with hepatocellular carcinoma. Those patients were prospective!}' studied by the Eastern Cooperative Oncology Group, and each had his or her diagnosis reconfirmed by a pathology review panel. There were 301 North American and 131 South African patients. Sixty-nine % of the North American patients and 82% of the South African patients were male. There were 187 Black patients, 62 of whom were from North America. The study population is unique among hepatocellular carcinoma pa tients in that eligibility, evaluability, and endpoint definitions were stand ardized, and patients from both North America and South Africa received similar treatments at a similar time. Factors with the most significant adverse effect on survival are im paired performance status, male sex, older age, and disease symptoms (jaundice and reduced appetite). There is no apparent difference in survival between White and Black patients within North America, but North American patients survived longer than South African patients. Among the different therapies, p.o. 5-fluorouracil was associated with the poorest median survival time (6 wk), and i.v. 5-fluorouracil plus semustine with the best median survival time (24 wk).
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