Phase II Trials of Interferons-α and -β in Advanced Sarcomas

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Journal Article
Journal of Interferon Research, 1992, 12 (6), pp. 455 - 458
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Interferons (IFNs)-α and -β were administered to patients with metastatic sarcomas in two different Eastern Cooperative Oncology Group studies. In one study, patients received IFN-α2b, 20 million units/m2 i.v. 5 days/week × 4, then 10 million units s.c. t.i.w. In the second study, patients received IFN-βser 180 million units t.i.w. Of 87 patients evaluable for response, there were three responses in 64 patients (5%) treated with IFN-α-2b and no responses in 23 patients treated with IFN-βser. Severe or life-threatening fatigue with decline in performance status complicated treatment of 37% of patients receiving IFN-α2b and 17% of patients receiving IFN-βser Further investigation of IFNs in sarcomas should depend on evidence from preclinical studies demonstrating synergistic effects of IFNs combined with a cytoreductive modality which has proven activity in these malignancies. © 1992, Mary Ann Liebert, Inc. All rights reserved.
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