Lower confidence bounds for time to cure

Oxford University Press
Publication Type:
Journal Article
Biometrika, 1993, 80 (3), pp. 681 - 687
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2012000107OK.pdf760.4 kB
Adobe PDF
Clinicians often wish to know if and when patients with cancer or other life-threatening diseases can be considered cured. Although some parametric approaches are available, no nonparametric methods exist for treating this question. Here, a nonparametric procedure based on the definition that cure occurs when the hazard for death among patients is-no longer greater than the hazard among subjects in the general, population with similar age and demographic characteristics is developed. It is argued that the use of a fully nonparametric approach cannot lead to a nontrivial upper confidence bound for time to cure, and an approach to computing lower confidence bounds for time to cure is developed and applied to data from a clinical trial in colorectal cancer.
Please use this identifier to cite or link to this item: