The prenatal detection of significant alcohol exposure with maternal blood markers

Stoler, JM; Huntington, KS; Peterson, CM; Peterson, KP; Daniel, P; Aboagye, KK; Lieberman, E; Ryan, L; Holmes, LB

The prenatal detection of significant alcohol exposure with maternal blood markers

Stoler, JM Huntington, KS Peterson, CM Peterson, KP Daniel, P Aboagye, KK Lieberman, E Ryan, L

Holmes, LB

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Publication Type:: Journal Article
Citation:: Journal of Pediatrics, 1998, 133 (3), pp. 346 - 352
Issue Date:: 1998-01-01

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Field	Value	Language
dc.contributor.author	Stoler, JM	en_US
dc.contributor.author	Huntington, KS	en_US
dc.contributor.author	Peterson, CM	en_US
dc.contributor.author	Peterson, KP	en_US
dc.contributor.author	Daniel, P	en_US
dc.contributor.author	Aboagye, KK	en_US
dc.contributor.author	Lieberman, E	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Holmes, LB	en_US
dc.date.issued	1998-01-01	en_US
dc.identifier.citation	Journal of Pediatrics, 1998, 133 (3), pp. 346 - 352	en_US
dc.identifier.issn	0022-3476	en_US
dc.identifier.uri	http://hdl.handle.net/10453/26249
dc.description.abstract	Objective: To examine the efficacy of a combination of 4 blood markers of alcohol use in detecting alcohol-abusing pregnant women. Study design: Two new markers of alcohol use, whole blood-associated acetaldehyde and carbohydrate-deficient transferrin, and 2 traditional markers of alcohol use, γ-glutamyl transpeptidase and mean red blood cell volume, were measured in the blood of pregnant women. Each woman was interviewed about alcohol and drug use, medical and obstetric histories, and nutrition. Each infant was examined by a clinician who was blinded to exposure status. Results: All of the women who reported drinking an average of 1 or more ounces of absolute alcohol per day had at least 1 positive blood marker. The infants of mothers with 2 or more positive markers had significantly smaller birth weights, lengths, and head circumferences than the infants with negative maternal screens. The presence of 2 or more positive markers was more predictive of infant outcome than any self-reporting measure. Conclusions: These markers, which detect more at-risk pregnant women than self-reporting methods, could lead to better efforts at detection and prevention of alcohol-induced fetal damage.	en_US
dc.relation.ispartof	Journal of Pediatrics	en_US
dc.relation.isbasedon	10.1016/S0022-3476(98)70267-7	en_US
dc.subject.classification	Pediatrics	en_US
dc.subject.mesh	Head	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Acetaldehyde	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Alcohol Drinking	en_US
dc.subject.mesh	Biomarkers	en_US
dc.subject.mesh	Birth Weight	en_US
dc.subject.mesh	Body Height	en_US
dc.subject.mesh	Erythrocyte Indices	en_US
dc.subject.mesh	Ethanol	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Fetal Alcohol Spectrum Disorders	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Medical History Taking	en_US
dc.subject.mesh	Nutritional Physiological Phenomena	en_US
dc.subject.mesh	Predictive Value of Tests	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Pregnancy Outcome	en_US
dc.subject.mesh	Prenatal Diagnosis	en_US
dc.subject.mesh	Prenatal Exposure Delayed Effects	en_US
dc.subject.mesh	Reproductive History	en_US
dc.subject.mesh	Single-Blind Method	en_US
dc.subject.mesh	Substance-Related Disorders	en_US
dc.subject.mesh	Transferrin	en_US
dc.subject.mesh	gamma-Glutamyltransferase	en_US
dc.title	The prenatal detection of significant alcohol exposure with maternal blood markers	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	133	en_US
utslib.for	010402 Biostatistics	en_US
utslib.for	1106 Human Movement and Sports Sciences	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	133	en_US

Abstract:

Objective: To examine the efficacy of a combination of 4 blood markers of alcohol use in detecting alcohol-abusing pregnant women. Study design: Two new markers of alcohol use, whole blood-associated acetaldehyde and carbohydrate-deficient transferrin, and 2 traditional markers of alcohol use, γ-glutamyl transpeptidase and mean red blood cell volume, were measured in the blood of pregnant women. Each woman was interviewed about alcohol and drug use, medical and obstetric histories, and nutrition. Each infant was examined by a clinician who was blinded to exposure status. Results: All of the women who reported drinking an average of 1 or more ounces of absolute alcohol per day had at least 1 positive blood marker. The infants of mothers with 2 or more positive markers had significantly smaller birth weights, lengths, and head circumferences than the infants with negative maternal screens. The presence of 2 or more positive markers was more predictive of infant outcome than any self-reporting measure. Conclusions: These markers, which detect more at-risk pregnant women than self-reporting methods, could lead to better efforts at detection and prevention of alcohol-induced fetal damage.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/26249