Folic acid-functionalized magnetic ZnFe<inf>2</inf>O<inf>4</inf> hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release

Yang, D; Wei, K; Liu, Q; Yang, Y; Guo, X; Rong, H; Cheng, ML; Wang, G

Folic acid-functionalized magnetic ZnFe<inf>2</inf>O<inf>4</inf> hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release

Yang, D Wei, K Liu, Q Yang, Y Guo, X Rong, H Cheng, ML Wang, G

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Publication Type:: Journal Article
Citation:: Materials Science and Engineering C, 2013, 33 (5), pp. 2879 - 2884
Issue Date:: 2013-07-01

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Field	Value	Language
dc.contributor.author	Yang, D	en_US
dc.contributor.author	Wei, K	en_US
dc.contributor.author	Liu, Q	en_US
dc.contributor.author	Yang, Y	en_US
dc.contributor.author	Guo, X	en_US
dc.contributor.author	Rong, H	en_US
dc.contributor.author	Cheng, ML	en_US
dc.contributor.author	Wang, G https://orcid.org/0000-0003-4295-8578	en_US
dc.date.available	2013-03-03	en_US
dc.date.issued	2013-07-01	en_US
dc.identifier.citation	Materials Science and Engineering C, 2013, 33 (5), pp. 2879 - 2884	en_US
dc.identifier.issn	0928-4931	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27569
dc.description.abstract	A drug delivery system was designed by deliberately combining the useful functions into one entity, which was composed of magnetic ZnFe2O 4 hollow microsphere as the core, and mesoporous silica with folic acid molecules as the outer shell. Amine groups coated magnetic ZnFe 2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NH2) composite particles were first synthesized by a one-pot direct co-condensation method. Subsequently a novel kind of folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NHFA) composite particles were synthesized by conjugating folic acid as targeted molecule to MZHM-MSS-NH 2. Ibuprofen, a well-known antiphlogistic drug, was used as a model drug to assess the loading and releasing behavior of the composite microspheres. The results show that the MZHM-MSS-NHFA system has the higher capacity of drug storage and good sustained drug-release property. © 2013 Elsevier B.V.	en_US
dc.relation.ispartof	Materials Science and Engineering C	en_US
dc.relation.isbasedon	10.1016/j.msec.2013.03.006	en_US
dc.subject.classification	Biomedical Engineering	en_US
dc.subject.mesh	Zinc	en_US
dc.subject.mesh	Ferric Compounds	en_US
dc.subject.mesh	Silicon Dioxide	en_US
dc.subject.mesh	Folic Acid	en_US
dc.subject.mesh	Drug Carriers	en_US
dc.subject.mesh	Microscopy, Electron, Transmission	en_US
dc.subject.mesh	Powder Diffraction	en_US
dc.subject.mesh	Microspheres	en_US
dc.subject.mesh	Magnetics	en_US
dc.title	Folic acid-functionalized magnetic ZnFe<inf>2</inf>O<inf>4</inf> hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	33	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0912 Materials Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	33	en_US

Abstract:

A drug delivery system was designed by deliberately combining the useful functions into one entity, which was composed of magnetic ZnFe2O 4 hollow microsphere as the core, and mesoporous silica with folic acid molecules as the outer shell. Amine groups coated magnetic ZnFe 2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NH2) composite particles were first synthesized by a one-pot direct co-condensation method. Subsequently a novel kind of folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NHFA) composite particles were synthesized by conjugating folic acid as targeted molecule to MZHM-MSS-NH 2. Ibuprofen, a well-known antiphlogistic drug, was used as a model drug to assess the loading and releasing behavior of the composite microspheres. The results show that the MZHM-MSS-NHFA system has the higher capacity of drug storage and good sustained drug-release property. © 2013 Elsevier B.V.

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http://hdl.handle.net/10453/27569