Folic acid-functionalized magnetic ZnFe<inf>2</inf>O<inf>4</inf> hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release

Publication Type:
Journal Article
Citation:
Materials Science and Engineering C, 2013, 33 (5), pp. 2879 - 2884
Issue Date:
2013-07-01
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A drug delivery system was designed by deliberately combining the useful functions into one entity, which was composed of magnetic ZnFe2O 4 hollow microsphere as the core, and mesoporous silica with folic acid molecules as the outer shell. Amine groups coated magnetic ZnFe 2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NH2) composite particles were first synthesized by a one-pot direct co-condensation method. Subsequently a novel kind of folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NHFA) composite particles were synthesized by conjugating folic acid as targeted molecule to MZHM-MSS-NH 2. Ibuprofen, a well-known antiphlogistic drug, was used as a model drug to assess the loading and releasing behavior of the composite microspheres. The results show that the MZHM-MSS-NHFA system has the higher capacity of drug storage and good sustained drug-release property. © 2013 Elsevier B.V.
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