Psammaplysin F: A unique inhibitor of bacterial chromosomal partitioning

Publication Type:
Journal Article
Citation:
Bioorganic and Medicinal Chemistry Letters, 2013, 23 (17), pp. 4862 - 4866
Issue Date:
2013-09-01
Metrics:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2012007789OK.pdf706.15 kB
Adobe PDF
Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50 μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80 μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor. © 2013 Elsevier Ltd. All rights reserved.
Please use this identifier to cite or link to this item: