A conserved acetyl esterase domain targets diverse bacteriophages to the Vi capsular receptor of Salmonella enterica serovar typhi

Publication Type:
Journal Article
Citation:
Journal of Bacteriology, 2010, 192 (21), pp. 5746 - 5754
Issue Date:
2010-01-01
Metrics:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2012007780OK.pdf3.77 MB
Adobe PDF
A number of bacteriophages have been identified that target the Vi capsular antigen of Salmonella enterica serovar Typhi. Here we show that these Vi phages represent a remarkably diverse set of phages belonging to three phage families, including Podoviridae and Myoviridae. Genome analysis facilitated the further classifi-cation of these phages and highlighted aspects of their independent evolution. Significantly, a conserved protein domain carrying an acetyl esterase was found to be associated with at least one tail fiber gene for all Vi phages, and the presence of this domain was confirmed in representative phage particles by mass spectrometric analysis. Thus, we provide a simple explanation and paradigm of how a diverse group of phages target a single key virulence antigen associated with this important human-restricted pathogen. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Please use this identifier to cite or link to this item: