Nanodiamonds with silicon vacancy defects for nontoxic photostable fluorescent labeling of neural precursor cells

Merson, TD; Castelletto, S; Aharonovich, I; Turbic, A; Kilpatrick, TJ; Turnley, AM

Nanodiamonds with silicon vacancy defects for nontoxic photostable fluorescent labeling of neural precursor cells

Merson, TD Castelletto, S Aharonovich, I

Turbic, A Kilpatrick, TJ Turnley, AM

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Publication Type:: Journal Article
Citation:: Optics Letters, 2013, 38 (20), pp. 4170 - 4173
Issue Date:: 2013-10-15

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Field	Value	Language
dc.contributor.author	Merson, TD	en_US
dc.contributor.author	Castelletto, S	en_US
dc.contributor.author	Aharonovich, I https://orcid.org/0000-0003-4304-3935	en_US
dc.contributor.author	Turbic, A	en_US
dc.contributor.author	Kilpatrick, TJ	en_US
dc.contributor.author	Turnley, AM	en_US
dc.date.issued	2013-10-15	en_US
dc.identifier.citation	Optics Letters, 2013, 38 (20), pp. 4170 - 4173	en_US
dc.identifier.issn	0146-9592	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27859
dc.description.abstract	Nanodiamonds (NDs) containing silicon vacancy (SiV) defects were evaluated as a potential biomarker for the labeling and fluorescent imaging of neural precursor cells (NPCs). SiV-containing NDs were synthesized using chemical vapor deposition and silicon ion implantation. Spectrally, SiV-containing NDs exhibited extremely stable fluorescence and narrow bandwidth emission with an excellent signal to noise ratio exceeding that of NDs containing nitrogen-vacancy centers. NPCs labeled with NDs exhibited normal cell viability and proliferative properties consistent with biocompatibility. We conclude that SiV-containing NDs are a promising biomedical research tool for cellular labeling and optical imaging in stem cell research. © 2013 Optical Society of America.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DE130100592
dc.relation.ispartof	Optics Letters	en_US
dc.relation.isbasedon	10.1364/OL.38.004170	en_US
dc.rights	© 2013 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.	en_US
dc.subject.classification	Optics	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Silicon	en_US
dc.subject.mesh	Fluorescent Dyes	en_US
dc.subject.mesh	Staining and Labeling	en_US
dc.subject.mesh	Nanodiamonds	en_US
dc.subject.mesh	Neural Stem Cells	en_US
dc.title	Nanodiamonds with silicon vacancy defects for nontoxic photostable fluorescent labeling of neural precursor cells	en_US
dc.type	Journal Article
utslib.citation.volume	20	en_US
utslib.citation.volume	38	en_US
utslib.for	0205 Optical Physics	en_US
utslib.for	0206 Quantum Physics	en_US
utslib.for	0906 Electrical and Electronic Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	20	en_US
pubs.publication-status	Published	en_US
pubs.volume	38	en_US

Abstract:

Nanodiamonds (NDs) containing silicon vacancy (SiV) defects were evaluated as a potential biomarker for the labeling and fluorescent imaging of neural precursor cells (NPCs). SiV-containing NDs were synthesized using chemical vapor deposition and silicon ion implantation. Spectrally, SiV-containing NDs exhibited extremely stable fluorescence and narrow bandwidth emission with an excellent signal to noise ratio exceeding that of NDs containing nitrogen-vacancy centers. NPCs labeled with NDs exhibited normal cell viability and proliferative properties consistent with biocompatibility. We conclude that SiV-containing NDs are a promising biomedical research tool for cellular labeling and optical imaging in stem cell research. © 2013 Optical Society of America.

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http://hdl.handle.net/10453/27859