Bone regeneration of rat tibial defect by zinc-tricalcium phosphate (Zn-TCP) from porous Foraminifera carbonate macrospheres

Publisher:
MDPI
Publication Type:
Journal Article
Citation:
Marine Drugs, 2013, 11 (12), pp. 5148 - 5158
Issue Date:
2013-01
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Foraminifera carbonate exoskeleton was hydrothermally converted to biocompatible and biodegradable zinc-tricalcium phosphate (Zn-TCP) as an alternative biomimetic material for bone fracture repair. Zn-TCP samples implanted in a rat tibial defect model for eight weeks were compared with unfilled defect and beta-tricalcium phosphate showing accelerated bone regeneration compared with the control groups, with statistically significant bone mineral density and bone mineral content growth. CT images of the defect showed restoration of cancellous bone in Zn-TCP and only minimal growth in control group. Histological slices reveal bone in-growth within the pores and porous chamber of the material detailing good bone-material integration with the presence of blood vessels. These results exhibit the future potential of biomimetic Zn-TCP as bone grafts for bone fracture repair.
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