Parallel independent evolution of pathogenicity within the genus Yersinia

Reuter, S; Connor, TR; Barquist, L; Walker, D; Feltwell, T; Harris, SR; Fookes, M; Hall, ME; Petty, NK; Fuchs, TM; Corander, J; Dufour, M; Ringwood, T; Savin, C; Bouchier, C; Martin, L; Miettinen, M; Shubin, M; Riehm, JM; Laukkanen-Ninios, R; Sihvonen, LM; Siitonen, A; Skurnik, M; Falcão, JP; Fukushima, H; Scholz, HC; Prentice, MB; Wren, BW; Parkhill, J; Carniel, E; Achtman, M; McNally, A; Thomson, NR

Parallel independent evolution of pathogenicity within the genus Yersinia

Reuter, S Connor, TR Barquist, L Walker, D Feltwell, T Harris, SR Fookes, M Hall, ME Petty, NK

Fuchs, TM Corander, J Dufour, M Ringwood, T Savin, C Bouchier, C Martin, L Miettinen, M Shubin, M Riehm, JM Laukkanen-Ninios, R Sihvonen, LM Siitonen, A Skurnik, M Falcão, JP Fukushima, H Scholz, HC Prentice, MB Wren, BW Parkhill, J Carniel, E Achtman, M McNally, A Thomson, NR

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Publication Type:: Journal Article
Citation:: Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (18), pp. 6768 - 6773
Issue Date:: 2014-05-06

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Field	Value	Language
dc.contributor.author	Reuter, S	en_US
dc.contributor.author	Connor, TR	en_US
dc.contributor.author	Barquist, L	en_US
dc.contributor.author	Walker, D	en_US
dc.contributor.author	Feltwell, T	en_US
dc.contributor.author	Harris, SR	en_US
dc.contributor.author	Fookes, M	en_US
dc.contributor.author	Hall, ME	en_US
dc.contributor.author	Petty, NK https://orcid.org/0000-0001-6528-9886	en_US
dc.contributor.author	Fuchs, TM	en_US
dc.contributor.author	Corander, J	en_US
dc.contributor.author	Dufour, M	en_US
dc.contributor.author	Ringwood, T	en_US
dc.contributor.author	Savin, C	en_US
dc.contributor.author	Bouchier, C	en_US
dc.contributor.author	Martin, L	en_US
dc.contributor.author	Miettinen, M	en_US
dc.contributor.author	Shubin, M	en_US
dc.contributor.author	Riehm, JM	en_US
dc.contributor.author	Laukkanen-Ninios, R	en_US
dc.contributor.author	Sihvonen, LM	en_US
dc.contributor.author	Siitonen, A	en_US
dc.contributor.author	Skurnik, M	en_US
dc.contributor.author	Falcão, JP	en_US
dc.contributor.author	Fukushima, H	en_US
dc.contributor.author	Scholz, HC	en_US
dc.contributor.author	Prentice, MB	en_US
dc.contributor.author	Wren, BW	en_US
dc.contributor.author	Parkhill, J	en_US
dc.contributor.author	Carniel, E	en_US
dc.contributor.author	Achtman, M	en_US
dc.contributor.author	McNally, A	en_US
dc.contributor.author	Thomson, NR	en_US
dc.date.issued	2014-05-06	en_US
dc.identifier.citation	Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (18), pp. 6768 - 6773	en_US
dc.identifier.issn	0027-8424	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27923
dc.description.abstract	The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locus ail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.	en_US
dc.relation.ispartof	Proceedings of the National Academy of Sciences of the United States of America	en_US
dc.relation.isbasedon	10.1073/pnas.1317161111	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Yersinia	en_US
dc.subject.mesh	Yersinia enterocolitica	en_US
dc.subject.mesh	Evolution, Molecular	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Virulence	en_US
dc.subject.mesh	Species Specificity	en_US
dc.subject.mesh	Genome, Bacterial	en_US
dc.subject.mesh	Metabolic Networks and Pathways	en_US
dc.title	Parallel independent evolution of pathogenicity within the genus Yersinia	en_US
dc.type	Journal Article
utslib.citation.volume	18	en_US
utslib.citation.volume	111	en_US
utslib.for	110316 Pathology (excl. Oral Pathology)	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	18	en_US
pubs.publication-status	Published	en_US
pubs.volume	111	en_US

Abstract:

The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locus ail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/27923