Peptide Ligations Accelerated By N-Terminal Aspartate And Glutamate Residues

Amer Chemical Soc
Publication Type:
Journal Article
Organic Letters, 2011, 13 (18), pp. 4770 - 4773
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2013005059OK.pdf1.09 MB
Adobe PDF
A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated.
Please use this identifier to cite or link to this item: