Peptide ligations accelerated by N-terminal aspartate and glutamate residues

Publication Type:
Journal Article
Citation:
Organic Letters, 2011, 13 (18), pp. 4770 - 4773
Issue Date:
2011-09-16
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2013005059OK.pdf1.09 MB
Adobe PDF
A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated. © 2011 American Chemical Society.
Please use this identifier to cite or link to this item: