Subcompartmentalized Polymer Hydrogel Capsules with Selectively Degradable Carrier and Subunits

Publisher:
Wiley
Publication Type:
Journal Article
Citation:
Small, 2010, 6 (14), pp. 1558 - 1564
Issue Date:
2010-01
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Subcompartmentalized hydrogel capsules (SHCs) with selectively degradable carriers and subunits are designed for potential applications in drug delivery and microencapsulated biocatalysis. Thiolated poly(methacrylic acid) and poly(N-vinyl pyrrolidone) are used to assemble 3-µm-diameter carrier capsules and 300-nm-diameter subunits, independently stabilized by a diverse range of covalent linkages. This paper presents examples of SHCs with tens of subcompartments and their successful drug loading, as well as selective degradation of the SHC carrier and/or subunits in response to multiple chemical stimuli.
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