Subcompartmentalized polymer hydrogel capsules with selectively degradable carriers and subunits

Kulygin, O; Price, AD; Chong, SF; Städler, B; Zelikin, AN; Caruso, F

Subcompartmentalized polymer hydrogel capsules with selectively degradable carriers and subunits

Kulygin, O

Price, AD Chong, SF Städler, B Zelikin, AN Caruso, F

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Publication Type:: Journal Article
Citation:: Small, 2010, 6 (14), pp. 1558 - 1564
Issue Date:: 2010-07-19

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Field	Value	Language
dc.contributor.author	Kulygin, O https://orcid.org/0000-0001-8822-1024	en_US
dc.contributor.author	Price, AD	en_US
dc.contributor.author	Chong, SF	en_US
dc.contributor.author	Städler, B	en_US
dc.contributor.author	Zelikin, AN	en_US
dc.contributor.author	Caruso, F	en_US
dc.date.issued	2010-07-19	en_US
dc.identifier.citation	Small, 2010, 6 (14), pp. 1558 - 1564	en_US
dc.identifier.issn	1613-6810	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28450
dc.description.abstract	Subcompartmentalized hydrogel capsules (SHCs) with selectively degradable carriers and subunits are designed for potential applications in drug delivery and microencapsulated biocatalysis. Thiolated poly(methacrylic acid) and poly(N-vinyl pyrrolidone) are used to assemble 3-mm-diameter carrier capsules and 300-nm-diameter subunits, independently stabilized by a diverse range of covalent linkages. This paper presents examples of SHCs with tens of subcompartments and their successful drug loading, as well as selective degradation of the SHC carrier and/or subunits in response to multiple chemical stimuli. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.	en_US
dc.relation.ispartof	Small	en_US
dc.relation.isbasedon	10.1002/smll.201000453	en_US
dc.subject.classification	Nanoscience & Nanotechnology	en_US
dc.subject.mesh	Polymethacrylic Acids	en_US
dc.subject.mesh	Polyvinyls	en_US
dc.subject.mesh	Pyrrolidines	en_US
dc.subject.mesh	Hydrogels	en_US
dc.subject.mesh	Drug Carriers	en_US
dc.subject.mesh	Microscopy, Electron, Transmission	en_US
dc.subject.mesh	Biocatalysis	en_US
dc.title	Subcompartmentalized polymer hydrogel capsules with selectively degradable carriers and subunits	en_US
dc.type	Journal Article
utslib.citation.volume	14	en_US
utslib.citation.volume	6	en_US
utslib.for	091205 Functional Materials	en_US
utslib.for	090301 Biomaterials	en_US
utslib.for	100703 Nanobiotechnology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	14	en_US
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

Subcompartmentalized hydrogel capsules (SHCs) with selectively degradable carriers and subunits are designed for potential applications in drug delivery and microencapsulated biocatalysis. Thiolated poly(methacrylic acid) and poly(N-vinyl pyrrolidone) are used to assemble 3-mm-diameter carrier capsules and 300-nm-diameter subunits, independently stabilized by a diverse range of covalent linkages. This paper presents examples of SHCs with tens of subcompartments and their successful drug loading, as well as selective degradation of the SHC carrier and/or subunits in response to multiple chemical stimuli. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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http://hdl.handle.net/10453/28450