Emerging mediators of airway smooth muscle dysfunction in asthma

Yeganeh, B; Xia, C; Movassagh, H; Koziol-White, C; Chang, Y; Al-Alwan, L; Bourke, JE; Oliver, BGG

Emerging mediators of airway smooth muscle dysfunction in asthma

Yeganeh, B Xia, C Movassagh, H Koziol-White, C Chang, Y Al-Alwan, L Bourke, JE Oliver, BGG

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Publication Type:: Journal Article
Citation:: Pulmonary Pharmacology and Therapeutics, 2013, 26 (1), pp. 105 - 111
Issue Date:: 2013-02-01

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Field	Value	Language
dc.contributor.author	Yeganeh, B	en_US
dc.contributor.author	Xia, C	en_US
dc.contributor.author	Movassagh, H	en_US
dc.contributor.author	Koziol-White, C	en_US
dc.contributor.author	Chang, Y	en_US
dc.contributor.author	Al-Alwan, L	en_US
dc.contributor.author	Bourke, JE	en_US
dc.contributor.author	Oliver, BGG https://orcid.org/0000-0002-7122-9262	en_US
dc.date.available	2012-06-27	en_US
dc.date.issued	2013-02-01	en_US
dc.identifier.citation	Pulmonary Pharmacology and Therapeutics, 2013, 26 (1), pp. 105 - 111	en_US
dc.identifier.issn	1094-5539	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28528
dc.description.abstract	Phenotypic changes in airway smooth muscle are integral to the pathophysiological changes that constitute asthma - namely inflammation, airway wall remodelling and bronchial hyperresponsiveness. In vitro and in vivo studies have shown that the proliferative, secretory and contractile functions of airway smooth muscle are dysfunctional in asthma. These functions can be modulated by various mediators whose levels are altered in asthma, derived from inflammatory cells or produced by airway smooth muscle itself. In this review, we describe the emerging roles of the CXC chemokines (GROs, IP-10), Th17-derived cytokines (IL-17, IL-22) and semaphorins, as well as the influence of viral infection on airway smooth muscle function, with a view to identifying new opportunities for therapeutic intervention in asthma. © 2012.	en_US
dc.relation.ispartof	Pulmonary Pharmacology and Therapeutics	en_US
dc.relation.isbasedon	10.1016/j.pupt.2012.06.011	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Muscle, Smooth	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Bronchial Hyperreactivity	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Semaphorins	en_US
dc.subject.mesh	Chemokines, CXC	en_US
dc.subject.mesh	Cytokines	en_US
dc.subject.mesh	Muscle Contraction	en_US
dc.subject.mesh	Phenotype	en_US
dc.subject.mesh	Airway Remodeling	en_US
dc.title	Emerging mediators of airway smooth muscle dysfunction in asthma	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	26	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	26	en_US

Abstract:

Phenotypic changes in airway smooth muscle are integral to the pathophysiological changes that constitute asthma - namely inflammation, airway wall remodelling and bronchial hyperresponsiveness. In vitro and in vivo studies have shown that the proliferative, secretory and contractile functions of airway smooth muscle are dysfunctional in asthma. These functions can be modulated by various mediators whose levels are altered in asthma, derived from inflammatory cells or produced by airway smooth muscle itself. In this review, we describe the emerging roles of the CXC chemokines (GROs, IP-10), Th17-derived cytokines (IL-17, IL-22) and semaphorins, as well as the influence of viral infection on airway smooth muscle function, with a view to identifying new opportunities for therapeutic intervention in asthma. © 2012.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/28528