TGF beta 1 Induces IL-6 and Inhibits IL-8 Release in Human Bronchial Epithelial Cells: The Role of Smad2/3
- Publisher:
- Wiley-Blackwell
- Publication Type:
- Journal Article
- Citation:
- Journal of Cellular Physiology, 2010, 225 (3), pp. 846 - 854
- Issue Date:
- 2010-01
Closed Access
Full metadata record
| Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ge, Q | en_US |
| dc.contributor.author | Moir, L | en_US |
| dc.contributor.author | Black, J | en_US |
| dc.contributor.author | Oliver, BG | en_US |
| dc.contributor.author | Burgess, J | en_US |
| dc.date.issued | 2010-01 | en_US |
| dc.identifier.citation | Journal of Cellular Physiology, 2010, 225 (3), pp. 846 - 854 | en_US |
| dc.identifier.issn | 0021-9541 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10453/28540 | |
| dc.description.abstract | Human bronchial epithelial (HBE) cells contribute to asthmatic airway inflammation by secreting cytokines, chemokines, and growth factors, including interleukin (IL)-6, IL-8 and transforming growth factor (TGF) beta 1, all of which are elevated in asthma | en_US |
| dc.publisher | Wiley-Blackwell | en_US |
| dc.relation.ispartof | Journal of Cellular Physiology | en_US |
| dc.relation.isbasedon | 10.1002/jcp.22295 | en_US |
| dc.subject.classification | Biochemistry & Molecular Biology | en_US |
| dc.subject.mesh | Bronchi | en_US |
| dc.subject.mesh | Respiratory Mucosa | en_US |
| dc.subject.mesh | Cells, Cultured | en_US |
| dc.subject.mesh | Epithelial Cells | en_US |
| dc.subject.mesh | Humans | en_US |
| dc.subject.mesh | Asthma | en_US |
| dc.subject.mesh | JNK Mitogen-Activated Protein Kinases | en_US |
| dc.subject.mesh | RNA, Messenger | en_US |
| dc.subject.mesh | Inflammation Mediators | en_US |
| dc.subject.mesh | Interleukin-8 | en_US |
| dc.subject.mesh | Interleukin-6 | en_US |
| dc.subject.mesh | Protein Kinase Inhibitors | en_US |
| dc.subject.mesh | Blotting, Western | en_US |
| dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | en_US |
| dc.subject.mesh | Case-Control Studies | en_US |
| dc.subject.mesh | Chromatin Immunoprecipitation | en_US |
| dc.subject.mesh | Polymerase Chain Reaction | en_US |
| dc.subject.mesh | Signal Transduction | en_US |
| dc.subject.mesh | Down-Regulation | en_US |
| dc.subject.mesh | Up-Regulation | en_US |
| dc.subject.mesh | Binding Sites | en_US |
| dc.subject.mesh | Phosphorylation | en_US |
| dc.subject.mesh | Adolescent | en_US |
| dc.subject.mesh | Adult | en_US |
| dc.subject.mesh | Aged | en_US |
| dc.subject.mesh | Middle Aged | en_US |
| dc.subject.mesh | Female | en_US |
| dc.subject.mesh | Male | en_US |
| dc.subject.mesh | Smad2 Protein | en_US |
| dc.subject.mesh | Smad3 Protein | en_US |
| dc.subject.mesh | Transforming Growth Factor beta1 | en_US |
| dc.subject.mesh | Promoter Regions, Genetic | en_US |
| dc.subject.mesh | Young Adult | en_US |
| dc.subject.mesh | Adolescent | en_US |
| dc.subject.mesh | Adult | en_US |
| dc.subject.mesh | Aged | en_US |
| dc.subject.mesh | Asthma | en_US |
| dc.subject.mesh | Binding Sites | en_US |
| dc.subject.mesh | Blotting, Western | en_US |
| dc.subject.mesh | Bronchi | en_US |
| dc.subject.mesh | Case-Control Studies | en_US |
| dc.subject.mesh | Cells, Cultured | en_US |
| dc.subject.mesh | Chromatin Immunoprecipitation | en_US |
| dc.subject.mesh | Down-Regulation | en_US |
| dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | en_US |
| dc.subject.mesh | Epithelial Cells | en_US |
| dc.subject.mesh | Female | en_US |
| dc.subject.mesh | Humans | en_US |
| dc.subject.mesh | Inflammation Mediators | en_US |
| dc.subject.mesh | Interleukin-6 | en_US |
| dc.subject.mesh | Interleukin-8 | en_US |
| dc.subject.mesh | JNK Mitogen-Activated Protein Kinases | en_US |
| dc.subject.mesh | Male | en_US |
| dc.subject.mesh | Middle Aged | en_US |
| dc.subject.mesh | Phosphorylation | en_US |
| dc.subject.mesh | Polymerase Chain Reaction | en_US |
| dc.subject.mesh | Promoter Regions, Genetic | en_US |
| dc.subject.mesh | Protein Kinase Inhibitors | en_US |
| dc.subject.mesh | RNA, Messenger | en_US |
| dc.subject.mesh | Respiratory Mucosa | en_US |
| dc.subject.mesh | Signal Transduction | en_US |
| dc.subject.mesh | Smad2 Protein | en_US |
| dc.subject.mesh | Smad3 Protein | en_US |
| dc.subject.mesh | Transforming Growth Factor beta1 | en_US |
| dc.subject.mesh | Up-Regulation | en_US |
| dc.subject.mesh | Young Adult | en_US |
| dc.title | TGF beta 1 Induces IL-6 and Inhibits IL-8 Release in Human Bronchial Epithelial Cells: The Role of Smad2/3 | en_US |
| dc.type | Journal Article | |
| utslib.citation.volume | 3 | en_US |
| utslib.citation.volume | 225 | en_US |
| utslib.for | 1116 Medical Physiology | en_US |
| utslib.for | 1116 Medical Physiology | en_US |
| pubs.embargo.period | Not known | en_US |
| pubs.organisational-group | /University of Technology Sydney | |
| pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
| pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
| pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
| utslib.copyright.status | closed_access | |
| pubs.declined | 1970-01-01T00:00:00.0+1000 | |
| pubs.consider-herdc | false | en_US |
| pubs.issue | 3 | en_US |
| pubs.notes | Peer review verified by Ulrichs - OK-AB | en_US |
| pubs.volume | 225 | en_US |
Files in This Item:
| Filename | Description | Size | |||
|---|---|---|---|---|---|
 | 2013005271OK.pdf | 1.17 MB | Adobe PDF |
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Abstract:
Human bronchial epithelial (HBE) cells contribute to asthmatic airway inflammation by secreting cytokines, chemokines, and growth factors, including interleukin (IL)-6, IL-8 and transforming growth factor (TGF) beta 1, all of which are elevated in asthma
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