Topical Review: Metallic Nanoparticles Array For Immunoassay

Amer Scientific Publishers
Publication Type:
Journal Article
Journal of Computational and Theoretical Nanoscience, 2010, 7 (10), pp. 1855 - 1869
Issue Date:
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Noble metal particles, especially gold (Au) and silver (Ag) nanoparticles exhibit unique and tunable optical properties on account of their surface plasmon resonance (SPR).It can be widely used in the field of immunoassay.In this paper, we reviewed the design, fabrication methods and applications of the nanoparticles.Discrete dipole approximation (DDA) and finite difference time domain (FDTD) methods applied brute-force computational methods for calculation and analysis of optical properties of different nanoparticles.Current nanotechnologies such as focused ion beam (FIB), nanosphere lithography (NSL), and laser interference lithography (LIL) make it possible to fabricate nanoparticles with arbitrary shapes.These nanoparticles are used to detect binding signals excited from biosamples for immunoassay such as antibody and antigen, amyloidderived diffusible ligands (ADDLs)-potential Alzheimers disease (AD) biomarkers, and Staphylococcal enterotixn B (SEB) in the concentration of nano-Moore per liter (nM) level.Finally , a biochip with multi-channel detection of biotin-streptavidin based on localized surface plasmon resonance was introduced.
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