Formation of 3-azabicyclo[3.3.1]non-3-enes: Imino amides vs. imino alkenes

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Journal Article
Monatshefte fur Chemie, 2014, 145 (6), pp. 983 - 992
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Formation of 3-azabicyclo[3.3.1]non-3-enes imino amides vs. imino alkenes.pdfPublished Version963.68 kB
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An effective method for synthesising alkaloid-like compounds containing the 3-azabicyclo[3.3.1]non-3-ene core structure was successfully carried out in a stereoselective manner via the bridged-Ritter reactions. Important optically active 6-alkyl(aryl)amido-4-alkyl(aryl)-2,2,6-trimethyl-3-azabicyclo[3.3.1]non- 3-enes (imino amides) and 4-alkyl(aryl)-2,2,6-trimethyl-3-azabicyclo[3.3.1]nona- 3,6-dienes (imino alkenes) were obtained in one step from (-)-β-pinene and the respective nitriles in the presence of concentrated H2SO4. The relative compositions of these products were controlled by varying the reaction conditions. Kinetic studies were conducted to enable a mechanistic understanding of the reaction pathways. Graphical Abstract: [Figure not available: see fulltext.] © 2014 Springer-Verlag Wien.
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