Bacterial mechanosensitive channels: Models for studying mechanosensory transduction

Martinac, B; Nomura, T; Chi, G; Petrov, E; Rohde, PR; Battle, AR; Foo, A; Constantine, M; Rothnagel, R; Carne, S; Deplazes, E; Cornell, B; Cranfield, CG; Hankamer, B; Landsberg, MJ

Bacterial mechanosensitive channels: Models for studying mechanosensory transduction

Martinac, B Nomura, T Chi, G Petrov, E Rohde, PR Battle, AR Foo, A Constantine, M Rothnagel, R Carne, S Deplazes, E

Cornell, B

Cranfield, CG

Hankamer, B Landsberg, MJ

Permalink

Publication Type:: Journal Article
Citation:: Antioxidants and Redox Signaling, 2014, 20 (6), pp. 952 - 969
Issue Date:: 2014-02-20

Closed Access

	Filename	Description	Size
	antioxidants and redox signaling 2014.pdf	Published Version	1.33 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Martinac, B	en_US
dc.contributor.author	Nomura, T	en_US
dc.contributor.author	Chi, G	en_US
dc.contributor.author	Petrov, E	en_US
dc.contributor.author	Rohde, PR	en_US
dc.contributor.author	Battle, AR	en_US
dc.contributor.author	Foo, A	en_US
dc.contributor.author	Constantine, M	en_US
dc.contributor.author	Rothnagel, R	en_US
dc.contributor.author	Carne, S	en_US
dc.contributor.author	Deplazes, E https://orcid.org/0000-0003-2052-5536	en_US
dc.contributor.author	Cornell, B https://orcid.org/0000-0003-4166-3241	en_US
dc.contributor.author	Cranfield, CG https://orcid.org/0000-0003-3608-5440	en_US
dc.contributor.author	Hankamer, B	en_US
dc.contributor.author	Landsberg, MJ	en_US
dc.date.issued	2014-02-20	en_US
dc.identifier.citation	Antioxidants and Redox Signaling, 2014, 20 (6), pp. 952 - 969	en_US
dc.identifier.issn	1523-0864	en_US
dc.identifier.uri	http://hdl.handle.net/10453/30154
dc.description.abstract	Significance: Sensations of touch and hearing are manifestations of mechanical contact and air pressure acting on touch receptors and hair cells of the inner ear, respectively. In bacteria, osmotic pressure exerts a significant mechanical force on their cellular membrane. Bacteria have evolved mechanosensitive (MS) channels to cope with excessive turgor pressure resulting from a hypo-osmotic shock. MS channel opening allows the expulsion of osmolytes and water, thereby restoring normal cellular turgor and preventing cell lysis. Recent Advances: As biological force-sensing systems, MS channels have been identified as the best examples of membrane proteins coupling molecular dynamics to cellular mechanics. The bacterial MS channel of large conductance (MscL) and MS channel of small conductance (MscS) have been subjected to extensive biophysical, biochemical, genetic, and structural analyses. These studies have established MscL and MscS as model systems for mechanosensory transduction. Critical Issues: In recent years, MS ion channels in mammalian cells have moved into focus of mechanotransduction research, accompanied by an increased awareness of the role they may play in the pathophysiology of diseases, including cardiac hypertrophy, muscular dystrophy, or Xerocytosis. Future Directions: A recent exciting development includes the molecular identification of Piezo proteins, which function as nonselective cation channels in mechanosensory transduction associated with senses of touch and pain. Since research on Piezo channels is very young, applying lessons learned from studies of bacterial MS channels to establishing the mechanism by which the Piezo channels are mechanically activated remains one of the future challenges toward a better understanding of the role that MS channels play in mechanobiology. Antioxid. Redox Signal. 20, 952-969. © 2014 Mary Ann Liebert, Inc.	en_US
dc.relation.ispartof	Antioxidants and Redox Signaling	en_US
dc.relation.isbasedon	10.1089/ars.2013.5471	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Cell Membrane	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Bacteria	en_US
dc.subject.mesh	Mechanotransduction, Cellular	en_US
dc.subject.mesh	Models, Biological	en_US
dc.title	Bacterial mechanosensitive channels: Models for studying mechanosensory transduction	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	20	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	20	en_US

Abstract:

Significance: Sensations of touch and hearing are manifestations of mechanical contact and air pressure acting on touch receptors and hair cells of the inner ear, respectively. In bacteria, osmotic pressure exerts a significant mechanical force on their cellular membrane. Bacteria have evolved mechanosensitive (MS) channels to cope with excessive turgor pressure resulting from a hypo-osmotic shock. MS channel opening allows the expulsion of osmolytes and water, thereby restoring normal cellular turgor and preventing cell lysis. Recent Advances: As biological force-sensing systems, MS channels have been identified as the best examples of membrane proteins coupling molecular dynamics to cellular mechanics. The bacterial MS channel of large conductance (MscL) and MS channel of small conductance (MscS) have been subjected to extensive biophysical, biochemical, genetic, and structural analyses. These studies have established MscL and MscS as model systems for mechanosensory transduction. Critical Issues: In recent years, MS ion channels in mammalian cells have moved into focus of mechanotransduction research, accompanied by an increased awareness of the role they may play in the pathophysiology of diseases, including cardiac hypertrophy, muscular dystrophy, or Xerocytosis. Future Directions: A recent exciting development includes the molecular identification of Piezo proteins, which function as nonselective cation channels in mechanosensory transduction associated with senses of touch and pain. Since research on Piezo channels is very young, applying lessons learned from studies of bacterial MS channels to establishing the mechanism by which the Piezo channels are mechanically activated remains one of the future challenges toward a better understanding of the role that MS channels play in mechanobiology. Antioxid. Redox Signal. 20, 952-969. © 2014 Mary Ann Liebert, Inc.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/30154