A delicate balance: Iron metabolism and diseases of the brain

Hare, D; Ayton, S; Bush, A; Lei, P

A delicate balance: Iron metabolism and diseases of the brain

Hare, D

Ayton, S Bush, A Lei, P

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Publication Type:: Journal Article
Citation:: Frontiers in Aging Neuroscience, 2013, 5 (JUL)
Issue Date:: 2013-09-11

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Field	Value	Language
dc.contributor.author	Hare, D https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Ayton, S	en_US
dc.contributor.author	Bush, A	en_US
dc.contributor.author	Lei, P	en_US
dc.date.available	2013-06-25	en_US
dc.date.issued	2013-09-11	en_US
dc.identifier.citation	Frontiers in Aging Neuroscience, 2013, 5 (JUL)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/30721
dc.description.abstract	Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential to life, yet this same chemistry mediates deleterious reactions with oxygen that induce oxidative stress. Consequently, there is a precise and tightly controlled mechanism to regulate iron in the brain. When iron is dysregulated, both conditions of iron overload and iron deficiencies are harmful to the brain. This review focuses on how iron metabolism is maintained in the brain, and how an alteration to iron and iron metabolism adversely affects neurological function. © 2013 Hare, Ayton, Bush and Lei.	en_US
dc.relation.ispartof	Frontiers in Aging Neuroscience	en_US
dc.relation.isbasedon	10.3389/fnagi.2013.00034	en_US
dc.title	A delicate balance: Iron metabolism and diseases of the brain	en_US
dc.type	Journal Article
utslib.citation.volume	JUL	en_US
utslib.citation.volume	5	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	060105 Cell Neurochemistry	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1702 Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.issue	JUL	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential to life, yet this same chemistry mediates deleterious reactions with oxygen that induce oxidative stress. Consequently, there is a precise and tightly controlled mechanism to regulate iron in the brain. When iron is dysregulated, both conditions of iron overload and iron deficiencies are harmful to the brain. This review focuses on how iron metabolism is maintained in the brain, and how an alteration to iron and iron metabolism adversely affects neurological function. © 2013 Hare, Ayton, Bush and Lei.

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http://hdl.handle.net/10453/30721