Bacterial ABC Transporters: Structure and Function
- Horizon Scientific Press
- Publication Type:
- Bacterial Membranes: Structural and Molecular Biology, 2014, 1
- Issue Date:
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ATP-Binding-Cassette (ABC) membrane transporters belong to one of the largest and most ancient gene families, occurring in bacteria, archaea, and eukaryota. In addition to nutrient uptake, ABC transporters are involved in other diverse processes such as the export of toxins, peptides, proteins, antibiotics, polysaccharides and lipids, and in cell division, bacterial immunity and nodulation in plants. While prokaryotic ABC transporters encompass both importers and exporters, eukaryotes harbour only exporters. Bacterial ABC transporters are intricately involved either directly or indirectly in all aspects of cellular physiology, metabolism, homeostasis, drug resistance, secretion, and cellular division. Whilst several complete ABC transporter structures have been solved over the past decade, their functional mechanism of transport is still somewhat controversial and this aspect is discussed in detail.
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