Bacterial ABC Transporters: Structure and Function

George, AM; Jones, PM

Bacterial ABC Transporters: Structure and Function

George, AM

Jones, PM

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Publisher:: Horizon Scientific Press
Publication Type:: Chapter
Citation:: Bacterial Membranes: Structural and Molecular Biology, 2014, 1
Issue Date:: 2014-01

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Field	Value	Language
dc.contributor.author	George, AM https://orcid.org/0000-0003-4691-8960	en_US
dc.contributor.author	Jones, PM	en_US
dc.contributor.editor	Han Renaut	en_US
dc.date.issued	2014-01	en_US
dc.identifier.citation	Bacterial Membranes: Structural and Molecular Biology, 2014, 1	en_US
dc.identifier.isbn	978-1-908230-27-0	en_US
dc.identifier.uri	http://hdl.handle.net/10453/31117
dc.description.abstract	ATP-Binding-Cassette (ABC) membrane transporters belong to one of the largest and most ancient gene families, occurring in bacteria, archaea, and eukaryota. In addition to nutrient uptake, ABC transporters are involved in other diverse processes such as the export of toxins, peptides, proteins, antibiotics, polysaccharides and lipids, and in cell division, bacterial immunity and nodulation in plants. While prokaryotic ABC transporters encompass both importers and exporters, eukaryotes harbour only exporters. Bacterial ABC transporters are intricately involved either directly or indirectly in all aspects of cellular physiology, metabolism, homeostasis, drug resistance, secretion, and cellular division. Whilst several complete ABC transporter structures have been solved over the past decade, their functional mechanism of transport is still somewhat controversial and this aspect is discussed in detail.	en_US
dc.publisher	Horizon Scientific Press	en_US
dc.relation.ispartof	Bacterial Membranes: Structural and Molecular Biology	en_US
dc.title	Bacterial ABC Transporters: Structure and Function	en_US
dc.type	Chapter
utslib.location	Norwich, UK	en_US
utslib.citation.edition	1	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.consider-herdc	false	en_US
pubs.edition	1	en_US
pubs.place-of-publication	Norwich, UK	en_US

Abstract:

ATP-Binding-Cassette (ABC) membrane transporters belong to one of the largest and most ancient gene families, occurring in bacteria, archaea, and eukaryota. In addition to nutrient uptake, ABC transporters are involved in other diverse processes such as the export of toxins, peptides, proteins, antibiotics, polysaccharides and lipids, and in cell division, bacterial immunity and nodulation in plants. While prokaryotic ABC transporters encompass both importers and exporters, eukaryotes harbour only exporters. Bacterial ABC transporters are intricately involved either directly or indirectly in all aspects of cellular physiology, metabolism, homeostasis, drug resistance, secretion, and cellular division. Whilst several complete ABC transporter structures have been solved over the past decade, their functional mechanism of transport is still somewhat controversial and this aspect is discussed in detail.

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http://hdl.handle.net/10453/31117