Uptake, depuration, and radiation dose estimation in zebrafish exposed to radionuclides via aqueous or dietary routes

Publisher:
Elsevier B.V.
Publication Type:
Journal Article
Citation:
Science of the Total Environment, 2011, 409 pp. 3771 - 3779
Issue Date:
2011-01
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Understanding uptake and depuration of radionuclides in organisms is necessary to relate exposure to radiation dose and ultimately to biological effects. We investigated uptake and depuration of a mixture of radionuclides to link bioaccumulation with radiation dose in zebrafish, Danio rerio. Adult zebrafish were exposed to radionuclides (54Mn, 60Co, 65Zn, 75Se, 109Cd, 110mAg, 134Cs and 241Am) at tracer levels (< 200 Bq g-1) for 14 d, either via water or diet. Radioactivity concentrations were measured in whole body and excised gonads of exposed fish during uptake (14 d) and depuration phases (47 d and 42 d for aqueous and dietary exposures respectively), and dose rates were modelled from activity concentrations in whole body and exposure medium (water or diet). After 14-day aqueous exposure, radionuclides were detected in decreasing activity concentrations: 75Se > 65Zn > 109Cd > 110mAg > 54Mn > 60Co > 241Am > 134Cs (range: 1758 Bq g1). After dietary exposure the order of radionuclide activity concentration in tissues (Bq g-1) was: 65Zn > 60Co > 75Se > 109Cd > 110mAg > 241Am > 54Mn > 134Cs (range: 911 Bq g-1). Aqueous exposure resulted in higher whole body activity concentrations for all radionuclides except 60Co.
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