Genomic interplay in bacterial communities: implications for growth promoting practices in animal husbandry.

Publisher:
Frontiers Media S.A.
Publication Type:
Journal Article
Citation:
Frontiers in Microbiology, 2014, 12 (5), pp. 394 - 394
Issue Date:
2014-01
Full metadata record
Files in This Item:
Thediscoveryofantibioticsheraldedthestartofa“GoldenAge”inthehistoryofmedicine.Overtheyears,theuseofantibioticsextendedbeyondmedicalpracticeintoanimalhusbandry,aquacultureandagriculture.Now,however,wefacetheworldwidethreatofdiseasescausedbypathogenicbacteriathatareresistanttoallexistingmajorclassesofantibiotic,reflectingthepossibilityofanendtotheantibioticera.Theseriousnessofthethreatisunderscoredbytheseverelylimitedproductionofnewclassesofantibiotics.Evolutionofbacteriaresistanttomultipleantibioticsresultsfromtheinherentgeneticcapabilitythatbacteriahavetoadaptrapidlytochangingenvironmentalconditions.Consequently,underantibioticselectionpressures,bacteriahaveacquiredresistancetoallclassesofantibiotics,sometimesveryshortlyaftertheirintroduction.Arguably,theevolutionandrapiddisseminationofmultipledrugresistantgenesen-masseacrossmicrobialpathogensisoneofthemostseriousthreatstohumanhealth.Inthiscontext,effectivesurveillancestrategiestotrackthedevelopmentofresistancetomultipleantibioticsarevitaltomanagingglobalinfectioncontrol.Thesesurveillancestrategiesarenecessaryfornotonlyhumanhealthbutalsoforanimalhealth,aquacultureandplantproduction.Shortfallsinthepresentsurveillancestrategiesneedtobeidentified.Raisingawarenessofthegeneticeventsthatpromoteco-selectionofresistancetomultipleantimicrobialsisanimportantprerequisitetothedesignandimplementationofmolecularsurveillancestrategies.Inthisreviewwewilldiscusshowlateralgenetransfer(LGT),drivenbytheuseoflow-doseantibioticsinanimalhusbandry,haslikelyplayedasignificantroleintheevolutionofmultipledrugresistance(MDR)inGram-negativebacteriaandhascomplicatedmolecularsurveillancestrategiesadoptedforpredictingimminentresistancethreats.
Please use this identifier to cite or link to this item: