Traumatic brain injury induces elevation of Co in the human brain

Roberts, BR; Hare, DJ; McLean, CA; Conquest, A; Lind, M; Li, QX; Bush, AI; Masters, CL; Morganti-Kossmann, MC; Frugier, T

Traumatic brain injury induces elevation of Co in the human brain

Roberts, BR Hare, DJ

McLean, CA Conquest, A Lind, M Li, QX Bush, AI Masters, CL Morganti-Kossmann, MC Frugier, T

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Publication Type:: Journal Article
Citation:: Metallomics, 2015, 7 (1), pp. 124 - 128
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Roberts, BR	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	McLean, CA	en_US
dc.contributor.author	Conquest, A	en_US
dc.contributor.author	Lind, M	en_US
dc.contributor.author	Li, QX	en_US
dc.contributor.author	Bush, AI	en_US
dc.contributor.author	Masters, CL	en_US
dc.contributor.author	Morganti-Kossmann, MC	en_US
dc.contributor.author	Frugier, T	en_US
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	Metallomics, 2015, 7 (1), pp. 124 - 128	en_US
dc.identifier.issn	1756-5901	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32808
dc.description.abstract	© 2015 The Royal Society of Chemistry. Traumatic brain injury (TBI) is the most common cause of death and disability in young adults, yet the molecular mechanisms that follow TBI are poorly understood. We previously reported a perturbation in iron (Fe) levels following TBI. Here we report that the distribution of cobalt (Co) is modulated in post-mortem human brain following injury. We also investigated how the distribution of other biologically relevant elements changes in TBI. Cobalt is increased due to TBI while copper (Cu), magnesium (Mg), manganese (Mn), phosphorus (P), potassium (K), rubidium (Rb), selenium (Se) and zinc (Zn) remain unchanged. The elevated Co has important implications for positron emission tomography neuroimaging. This is the first demonstration of the accumulation of Co in injured tissue explaining the previous utility of 55Co-PET imaging in TBI.	en_US
dc.relation.ispartof	Metallomics	en_US
dc.relation.isbasedon	10.1039/c4mt00258j	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Brain Injuries	en_US
dc.subject.mesh	Metals, Heavy	en_US
dc.subject.mesh	Cobalt	en_US
dc.subject.mesh	Autopsy	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Brain Chemistry	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Traumatic brain injury induces elevation of Co in the human brain	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	7	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© 2015 The Royal Society of Chemistry. Traumatic brain injury (TBI) is the most common cause of death and disability in young adults, yet the molecular mechanisms that follow TBI are poorly understood. We previously reported a perturbation in iron (Fe) levels following TBI. Here we report that the distribution of cobalt (Co) is modulated in post-mortem human brain following injury. We also investigated how the distribution of other biologically relevant elements changes in TBI. Cobalt is increased due to TBI while copper (Cu), magnesium (Mg), manganese (Mn), phosphorus (P), potassium (K), rubidium (Rb), selenium (Se) and zinc (Zn) remain unchanged. The elevated Co has important implications for positron emission tomography neuroimaging. This is the first demonstration of the accumulation of Co in injured tissue explaining the previous utility of 55Co-PET imaging in TBI.

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http://hdl.handle.net/10453/32808