Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation

Hare, DJ; Doecke, JD; Faux, NG; Rembach, A; Volitakis, I; Fowler, CJ; Grimm, R; Doble, PA; Cherny, RA; Masters, CL; Bush, AI; Roberts, BR

Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation

Hare, DJ

Doecke, JD Faux, NG Rembach, A Volitakis, I Fowler, CJ Grimm, R Doble, PA

Cherny, RA Masters, CL Bush, AI Roberts, BR

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Publication Type:: Journal Article
Citation:: ACS Chemical Neuroscience, 2015, 6 (3), pp. 398 - 402
Issue Date:: 2015-03-18

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Field	Value	Language
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Doecke, JD	en_US
dc.contributor.author	Faux, NG	en_US
dc.contributor.author	Rembach, A	en_US
dc.contributor.author	Volitakis, I	en_US
dc.contributor.author	Fowler, CJ	en_US
dc.contributor.author	Grimm, R	en_US
dc.contributor.author	Doble, PA https://orcid.org/0000-0002-8472-1301	en_US
dc.contributor.author	Cherny, RA	en_US
dc.contributor.author	Masters, CL	en_US
dc.contributor.author	Bush, AI	en_US
dc.contributor.author	Roberts, BR	en_US
dc.date.issued	2015-03-18	en_US
dc.identifier.citation	ACS Chemical Neuroscience, 2015, 6 (3), pp. 398 - 402	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32809
dc.identifier.uri	http://hdl.handle.net/10453/36518
dc.description.abstract	© 2015 American Chemical Society. Plasma iron levels are decreased in Alzheimer's disease (AD) and associated with an idiopathic anemia. We examined iron-binding plasma proteins from AD patients and healthy controls from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing using size exclusion chromatography-inductively coupled plasma-mass spectrometry. Peak area corresponding to transferrin (Tf) saturation was directly compared to routine pathological testing. We found a significant decrease in transferrin-associated iron in AD that was missed by routine pathological tests of transferrin saturation, and that was able to discriminate between AD and controls. The AD cases showed no significant difference in transferrin concentration, only a decrease in total transferrin-bound iron. These findings support that a previously identified decrease in plasma iron levels in AD patients within the AIBL study is attributable to decreased loading of iron into transferrin, and that this subtle but discriminatory change is not observed through routine pathological testing.	en_US
dc.relation.ispartof	ACS Chemical Neuroscience	en_US
dc.relation.isbasedon	10.1021/cn5003557	en_US
dc.subject.mesh	Plasma	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Alzheimer Disease	en_US
dc.subject.mesh	Iron	en_US
dc.subject.mesh	Transferrin	en_US
dc.subject.mesh	Chromatography, Gel	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Mass Spectrometry	en_US
dc.title	Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	6	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

© 2015 American Chemical Society. Plasma iron levels are decreased in Alzheimer's disease (AD) and associated with an idiopathic anemia. We examined iron-binding plasma proteins from AD patients and healthy controls from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing using size exclusion chromatography-inductively coupled plasma-mass spectrometry. Peak area corresponding to transferrin (Tf) saturation was directly compared to routine pathological testing. We found a significant decrease in transferrin-associated iron in AD that was missed by routine pathological tests of transferrin saturation, and that was able to discriminate between AD and controls. The AD cases showed no significant difference in transferrin concentration, only a decrease in total transferrin-bound iron. These findings support that a previously identified decrease in plasma iron levels in AD patients within the AIBL study is attributable to decreased loading of iron into transferrin, and that this subtle but discriminatory change is not observed through routine pathological testing.

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http://hdl.handle.net/10453/32809