Non-Viral Nano-Vectors for Nucleic Acid Delivery

Ting, SRS; Min, EH; Cortie, MB; Nguyen, HT; Hutvagner, G

Non-Viral Nano-Vectors for Nucleic Acid Delivery

Ting, SRS

Min, EH Cortie, MB

Nguyen, HT

Hutvagner, G

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Publisher:: Bentham Science Publishers
Publication Type:: Chapter
Citation:: Frontiers in Nanomedicine, 2015, 1, 1 pp. 222 - 255
Issue Date:: 2015-04-21

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Field	Value	Language
dc.contributor.author	Ting, SRS https://orcid.org/0000-0002-7787-7906	en_US
dc.contributor.author	Min, EH	en_US
dc.contributor.author	Cortie, MB https://orcid.org/0000-0003-3202-6398	en_US
dc.contributor.author	Nguyen, HT https://orcid.org/0000-0003-3373-8178	en_US
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.contributor.editor	Bondi, ML	en_US
dc.contributor.editor	Botto, C	en_US
dc.contributor.editor	Amore, E	en_US
dc.date.issued	2015-04-21	en_US
dc.identifier.citation	Frontiers in Nanomedicine, 2015, 1, 1 pp. 222 - 255	en_US
dc.identifier.isbn	978-1-68108-047-5	en_US
dc.identifier.uri	http://hdl.handle.net/10453/35250
dc.description.abstract	The development of therapeutic nucleic acids has led to new strategies for treating various diseases. Non-viral, synthetic nano-vectors in gene therapy have attracted increasing attention due to their low immunogenicity and low toxicity compared to viral counterparts. Due to the molecular structure of nucleic acids, they are very prone to degradation in pH sensitive biological environments. Therefore, synthetic nano-vehicles for therapeutic delivery, known as ‘nano-vectors’, need to be cleverly designed and engineered to protect and deliver appropriate therapeutic nucleic acids to the targeted sites for action. In this chapter, a brief overview of various types of therapeutic nucleic acids is first provided, followed by analysis of the synthetic nanomaterials under development as delivery systems to carry nucleic acids. The nucleic acid-encapsulated nano-vectors discussed here open a window for a new generation of nanomedicine.	en_US
dc.publisher	Bentham Science Publishers	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1054011
dc.relation.ispartof	Frontiers in Nanomedicine	en_US
dc.relation.isbasedon	10.2174/240591371150101	en_US
dc.title	Non-Viral Nano-Vectors for Nucleic Acid Delivery	en_US
dc.type	Chapter
utslib.citation.volume	1	en_US
utslib.location	UAE	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.citation.edition	1	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.consider-herdc	true	en_US
pubs.edition	1	en_US
pubs.place-of-publication	UAE	en_US
pubs.publication-status	Published	en_US
pubs.volume	1	en_US

Abstract:

The development of therapeutic nucleic acids has led to new strategies for treating various diseases. Non-viral, synthetic nano-vectors in gene therapy have attracted increasing attention due to their low immunogenicity and low toxicity compared to viral counterparts. Due to the molecular structure of nucleic acids, they are very prone to degradation in pH sensitive biological environments. Therefore, synthetic nano-vehicles for therapeutic delivery, known as ‘nano-vectors’, need to be cleverly designed and engineered to protect and deliver appropriate therapeutic nucleic acids to the targeted sites for action. In this chapter, a brief overview of various types of therapeutic nucleic acids is first provided, followed by analysis of the synthetic nanomaterials under development as delivery systems to carry nucleic acids. The nucleic acid-encapsulated nano-vectors discussed here open a window for a new generation of nanomedicine.

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http://hdl.handle.net/10453/35250