Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: Systematic review and meta-analysis

Archer, NS; Nassif, NT; O'Brien, BA

Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: Systematic review and meta-analysis

Archer, NS Nassif, NT

O'Brien, BA

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Publication Type:: Journal Article
Citation:: Genes and Immunity, 2015, 16 (4), pp. 275 - 283
Issue Date:: 2015-06-06

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Field	Value	Language
dc.contributor.author	Archer, NS	en_US
dc.contributor.author	Nassif, NT https://orcid.org/0000-0003-2675-8322	en_US
dc.contributor.author	O'Brien, BA https://orcid.org/0000-0001-5887-2424	en_US
dc.date.available	2020-05-25T19:13:26Z
dc.date.issued	2015-06-06	en_US
dc.identifier.citation	Genes and Immunity, 2015, 16 (4), pp. 275 - 283	en_US
dc.identifier.issn	1466-4879	en_US
dc.identifier.uri	http://hdl.handle.net/10453/35432
dc.description.abstract	© 2015 Macmillan Publishers Limited All rights reserved. A systematic review and meta-analyses were undertaken to investigate the association of SLC11A1 genetic variants with disease occurrence. Literature searching indentified 109 publications to include in the meta-analyses assessing the association of 11 SLC11A1 variants with autoimmune and infectious disease. The (GT) n promoter alleles 2 and 3 (rs534448891), which alter SLC11A1 expression, were significantly associated with tuberculosis (OR=1.47 (1.30-1.66), OR=0.76 (0.65-0.89), respectively) and infectious disease (OR=1.25 (1.10-1.42), OR=0.83 (0.74-0.93), respectively). However, although no association was observed with autoimmune disease, a modest significant association was observed with type 1 diabetes (allele 2 OR=0.94 (0.89-0.98)). On the basis of a stronger association of (GT) n allele 2 with tuberculosis, compared with the protective effect of allele 3, we hypothesise that allele 2 is likely the disease-causing variant influencing disease susceptibility. Significant associations were observed between the 469+14G/C polymorphism (rs3731865) and autoimmune disease (OR=1.30 (1.04-1.64)) and rheumatoid arthritis (OR=1.60 (1.20-2.13)) and between the -237C/T polymorphism (rs7573065) and inflammatory bowel disease (OR=0.60 (0.43-0.84)). Further, significant associations were identified between the 469+14G/C, 1730G/A and 1729+55del4 polymorphisms (rs3731865, rs17235409 and rs17235416, respectively) and both infectious disease per se and tuberculosis. These findings show a clear association between variants in the SLC11A1 locus and autoimmune and infectious disease susceptibility.	en_US
dc.relation.ispartof	Genes and Immunity	en_US
dc.relation.isbasedon	10.1038/gene.2015.8	en_US
dc.subject.classification	Immunology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Infection	en_US
dc.subject.mesh	Arthritis, Rheumatoid	en_US
dc.subject.mesh	Inflammatory Bowel Diseases	en_US
dc.subject.mesh	Autoimmune Diseases	en_US
dc.subject.mesh	Genetic Predisposition to Disease	en_US
dc.subject.mesh	Cation Transport Proteins	en_US
dc.subject.mesh	Polymorphism, Genetic	en_US
dc.subject.mesh	Polymorphism, Single Nucleotide	en_US
dc.subject.mesh	Promoter Regions, Genetic	en_US
dc.subject.mesh	Infections	en_US
dc.title	Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: Systematic review and meta-analysis	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	16	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	16	en_US

Abstract:

© 2015 Macmillan Publishers Limited All rights reserved. A systematic review and meta-analyses were undertaken to investigate the association of SLC11A1 genetic variants with disease occurrence. Literature searching indentified 109 publications to include in the meta-analyses assessing the association of 11 SLC11A1 variants with autoimmune and infectious disease. The (GT) n promoter alleles 2 and 3 (rs534448891), which alter SLC11A1 expression, were significantly associated with tuberculosis (OR=1.47 (1.30-1.66), OR=0.76 (0.65-0.89), respectively) and infectious disease (OR=1.25 (1.10-1.42), OR=0.83 (0.74-0.93), respectively). However, although no association was observed with autoimmune disease, a modest significant association was observed with type 1 diabetes (allele 2 OR=0.94 (0.89-0.98)). On the basis of a stronger association of (GT) n allele 2 with tuberculosis, compared with the protective effect of allele 3, we hypothesise that allele 2 is likely the disease-causing variant influencing disease susceptibility. Significant associations were observed between the 469+14G/C polymorphism (rs3731865) and autoimmune disease (OR=1.30 (1.04-1.64)) and rheumatoid arthritis (OR=1.60 (1.20-2.13)) and between the -237C/T polymorphism (rs7573065) and inflammatory bowel disease (OR=0.60 (0.43-0.84)). Further, significant associations were identified between the 469+14G/C, 1730G/A and 1729+55del4 polymorphisms (rs3731865, rs17235409 and rs17235416, respectively) and both infectious disease per se and tuberculosis. These findings show a clear association between variants in the SLC11A1 locus and autoimmune and infectious disease susceptibility.

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http://hdl.handle.net/10453/35432