The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica - A Leu(-12) to Pro(-12) replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular

Amer Soc Biochemistry Molecular Biology Inc
Publication Type:
Journal Article
Journal Of Biological Chemistry, 2007, 282 (22), pp. 16532 - 16543
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A protease secreted by the parasitic helminth Fasciola hepatica, a 37-kDa procathepsin L1 (FheproCL1), autocatalytically processes and activates to its mature enzyme (FheCL1) over a wide pH range of 7.3 to 4.0, although activation is more rapid at low pH
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