Bone regeneration of calvarial defect using marine calcareous-derived beta-tricalcium phosphate macrospheres

Chou, J; Hao, J; Kuroda, S; Ben-Nissan, B; Milthopre, B; Otsuka, M

Bone regeneration of calvarial defect using marine calcareous-derived beta-tricalcium phosphate macrospheres

Chou, J

Hao, J Kuroda, S Ben-Nissan, B Milthopre, B Otsuka, M

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Publication Type:: Journal Article
Citation:: Journal of Tissue Engineering, 2014, 5
Issue Date:: 2014-01-17

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Field	Value	Language
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Hao, J	en_US
dc.contributor.author	Kuroda, S	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Milthopre, B	en_US
dc.contributor.author	Otsuka, M	en_US
dc.date.available	2014-01-17	en_US
dc.date.issued	2014-01-17	en_US
dc.identifier.citation	Journal of Tissue Engineering, 2014, 5	en_US
dc.identifier.uri	http://hdl.handle.net/10453/35687
dc.description.abstract	© 2014, © The Author(s) 2014. The aim of this study was to examine the bone regeneration properties of beta-tricalcium phosphate hydrothermally converted from foraminifera carbonate exoskeleton in the repair of rat calvarial defect. These natural materials possess unique interconnected porous network with uniform pore size distribution, which can be potentially advantageous. In total, 20 adult male Wistar rats received full-thickness calvarial defect with a diameter of 5 mm. The rate of newly formed bone was measured radiologically by X-ray and micro-computed tomography and by histologic examination. After 2 weeks, the beta-tricalcium phosphate group exhibited full closure of the defect site, while control group remained unrestored at the end of the 6-week experimentation. It was observed that the newly regenerated bone thickened over the course of the experiment in the beta-tricalcium phosphate group. No soft tissue reaction was observed around the beta-tricalcium phosphate implant and the rats remained healthy. These results showed that repair of the calvarial defect can be achieved by biomimetic beta-tricalcium phosphate macrospheres, which hold potential for application as bone grafts for bone augmentation surgeries.	en_US
dc.relation.ispartof	Journal of Tissue Engineering	en_US
dc.relation.isbasedon	10.1177/2041731414523441	en_US
dc.title	Bone regeneration of calvarial defect using marine calcareous-derived beta-tricalcium phosphate macrospheres	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.for	1004 Medical Biotechnology	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

© 2014, © The Author(s) 2014. The aim of this study was to examine the bone regeneration properties of beta-tricalcium phosphate hydrothermally converted from foraminifera carbonate exoskeleton in the repair of rat calvarial defect. These natural materials possess unique interconnected porous network with uniform pore size distribution, which can be potentially advantageous. In total, 20 adult male Wistar rats received full-thickness calvarial defect with a diameter of 5 mm. The rate of newly formed bone was measured radiologically by X-ray and micro-computed tomography and by histologic examination. After 2 weeks, the beta-tricalcium phosphate group exhibited full closure of the defect site, while control group remained unrestored at the end of the 6-week experimentation. It was observed that the newly regenerated bone thickened over the course of the experiment in the beta-tricalcium phosphate group. No soft tissue reaction was observed around the beta-tricalcium phosphate implant and the rats remained healthy. These results showed that repair of the calvarial defect can be achieved by biomimetic beta-tricalcium phosphate macrospheres, which hold potential for application as bone grafts for bone augmentation surgeries.

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http://hdl.handle.net/10453/35687