Controlled Release of Simvastatin from Biomimetic β-TCP Drug Delivery System

Chou, J; Ito, T; Bishop, D; Otsuka, M; Ben-Nissan, B; Milthorpe, B

Controlled Release of Simvastatin from Biomimetic β-TCP Drug Delivery System

Chou, J

Ito, T Bishop, D

Otsuka, M Ben-Nissan, B Milthorpe, B

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Publication Type:: Journal Article
Citation:: PLoS ONE, 2013, 8 (1)
Issue Date:: 2013-01-18

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Field	Value	Language
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Ito, T	en_US
dc.contributor.author	Bishop, D https://orcid.org/0000-0002-6533-4410	en_US
dc.contributor.author	Otsuka, M	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Milthorpe, B https://orcid.org/0000-0002-0867-9586	en_US
dc.date.available	2012-12-13	en_US
dc.date.issued	2013-01-18	en_US
dc.identifier.citation	PLoS ONE, 2013, 8 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/35700
dc.description.abstract	Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means of hydrothermally converting marine exoskeletons to biocompatible beta-tricalcium phosphate was investigated. Furthermore, the release of simvastatin was controlled by the addition of an outer apatite coating layer. The samples were characterized by x-ray diffraction analysis, fourier transform infrared spectroscopy, scanning electron microscopy and mass spectroscopy confirming the conversion process. The in-vitro dissolution of key chemical compositional elements and the release of simvastatin were measured in simulated body fluid solution showing controlled release with reduction of approximately 25% compared with un-coated samples. This study shows the potential applications of marine structures as a drug delivery system for simvastatin. © 2013 Chou et al.	en_US
dc.relation.ispartof	PLoS ONE	en_US
dc.relation.isbasedon	10.1371/journal.pone.0054676	en_US
dc.subject.classification	General Science & Technology	en_US
dc.subject.mesh	Body Fluids	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Calcium Phosphates	en_US
dc.subject.mesh	Apatites	en_US
dc.subject.mesh	Simvastatin	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.subject.mesh	Spectroscopy, Fourier Transform Infrared	en_US
dc.subject.mesh	Biomimetics	en_US
dc.subject.mesh	Osteogenesis	en_US
dc.subject.mesh	Foraminifera	en_US
dc.subject.mesh	Aquatic Organisms	en_US
dc.title	Controlled Release of Simvastatin from Biomimetic β-TCP Drug Delivery System	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	8	en_US
utslib.for	MD Multidisciplinary	en_US
utslib.for	090301 Biomaterials	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means of hydrothermally converting marine exoskeletons to biocompatible beta-tricalcium phosphate was investigated. Furthermore, the release of simvastatin was controlled by the addition of an outer apatite coating layer. The samples were characterized by x-ray diffraction analysis, fourier transform infrared spectroscopy, scanning electron microscopy and mass spectroscopy confirming the conversion process. The in-vitro dissolution of key chemical compositional elements and the release of simvastatin were measured in simulated body fluid solution showing controlled release with reduction of approximately 25% compared with un-coated samples. This study shows the potential applications of marine structures as a drug delivery system for simvastatin. © 2013 Chou et al.

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http://hdl.handle.net/10453/35700