Metalloproteomics: Principles, challenges, and applications to neurodegeneration

Lothian, A; Hare, DJ; Grimm, R; Ryan, TM; Masters, CL; Roberts, BR

Metalloproteomics: Principles, challenges, and applications to neurodegeneration

Lothian, A Hare, DJ

Grimm, R Ryan, TM Masters, CL Roberts, BR

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Publication Type:: Journal Article
Citation:: Frontiers in Aging Neuroscience, 2013, 5 (JUL)
Issue Date:: 2013-09-11

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Field	Value	Language
dc.contributor.author	Lothian, A	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Grimm, R	en_US
dc.contributor.author	Ryan, TM	en_US
dc.contributor.author	Masters, CL	en_US
dc.contributor.author	Roberts, BR	en_US
dc.date.available	2013-06-25	en_US
dc.date.issued	2013-09-11	en_US
dc.identifier.citation	Frontiers in Aging Neuroscience, 2013, 5 (JUL)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/36160
dc.description.abstract	Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding of the mechanism and precise role of metalloenzymes and proteins in the brain. © 2013 Lothian, Hare, Grimm, Ryan, Masters and Roberts.	en_US
dc.relation.ispartof	Frontiers in Aging Neuroscience	en_US
dc.relation.isbasedon	10.3389/fnagi.2013.00035	en_US
dc.title	Metalloproteomics: Principles, challenges, and applications to neurodegeneration	en_US
dc.type	Journal Article
utslib.citation.volume	JUL	en_US
utslib.citation.volume	5	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1702 Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.issue	JUL	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding of the mechanism and precise role of metalloenzymes and proteins in the brain. © 2013 Lothian, Hare, Grimm, Ryan, Masters and Roberts.

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http://hdl.handle.net/10453/36160