Decreased copper in alzheimer's disease brain is predominantly in the soluble extractable fraction

Rembach, A; Hare, DJ; Lind, M; Fowler, CJ; Cherny, RA; McLean, C; Bush, AI; Masters, CL; Roberts, BR

Decreased copper in alzheimer's disease brain is predominantly in the soluble extractable fraction

Rembach, A Hare, DJ

Lind, M Fowler, CJ Cherny, RA McLean, C Bush, AI Masters, CL Roberts, BR

Permalink

Publication Type:: Journal Article
Citation:: International Journal of Alzheimer's Disease, 2013, 2013
Issue Date:: 2013-11-18

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published VersionAdobe PDF (591.29 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Rembach, A	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Lind, M	en_US
dc.contributor.author	Fowler, CJ	en_US
dc.contributor.author	Cherny, RA	en_US
dc.contributor.author	McLean, C	en_US
dc.contributor.author	Bush, AI	en_US
dc.contributor.author	Masters, CL	en_US
dc.contributor.author	Roberts, BR	en_US
dc.date.available	2013-09-20	en_US
dc.date.issued	2013-11-18	en_US
dc.identifier.citation	International Journal of Alzheimer's Disease, 2013, 2013	en_US
dc.identifier.uri	http://hdl.handle.net/10453/36161
dc.description.abstract	Alzheimer's disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society. The role of transition metals, in particular copper (Cu), in AD has become of significant interest due to the dyshomeostasis of these essential elements, which can impart profound effects on cell viability and neuronal function. We tested the hypothesis that there is a systemic perturbation in Cu compartmentalization in AD, within the brain as well as in the periphery, specifically within erythrocytes. Our results showed that the previously reported decrease in Cu within the human frontal cortex was confined to the soluble (P<0.05) and total homogenate (P<0.05) fractions. No differences were observed in Cu concentration in erythrocytes. Our data indicate that there is a brain specific alteration in Cu levels in AD localized to the soluble extracted material, which is not reflected in erythrocytes. Further studies using metalloproteomics approaches will be able to elucidate the metabolic mechanism(s) that results in the decreased brain Cu levels during the progression of AD. © 2013 Alan Rembach et al.	en_US
dc.relation.ispartof	International Journal of Alzheimer's Disease	en_US
dc.relation.isbasedon	10.1155/2013/623241	en_US
dc.title	Decreased copper in alzheimer's disease brain is predominantly in the soluble extractable fraction	en_US
dc.type	Journal Article
utslib.citation.volume	2013	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	2013	en_US

Abstract:

Alzheimer's disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society. The role of transition metals, in particular copper (Cu), in AD has become of significant interest due to the dyshomeostasis of these essential elements, which can impart profound effects on cell viability and neuronal function. We tested the hypothesis that there is a systemic perturbation in Cu compartmentalization in AD, within the brain as well as in the periphery, specifically within erythrocytes. Our results showed that the previously reported decrease in Cu within the human frontal cortex was confined to the soluble (P<0.05) and total homogenate (P<0.05) fractions. No differences were observed in Cu concentration in erythrocytes. Our data indicate that there is a brain specific alteration in Cu levels in AD localized to the soluble extracted material, which is not reflected in erythrocytes. Further studies using metalloproteomics approaches will be able to elucidate the metabolic mechanism(s) that results in the decreased brain Cu levels during the progression of AD. © 2013 Alan Rembach et al.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/36161