Extracellular ATP inhibits twitching motility-mediated biofilm expansion by Pseudomonas aeruginosa.

Nolan, LM; Cavaliere, R; Turnbull, L; Whitchurch, CB

Extracellular ATP inhibits twitching motility-mediated biofilm expansion by Pseudomonas aeruginosa.

Nolan, LM Cavaliere, R Turnbull, L

Whitchurch, CB

Permalink

Publication Type:: Journal Article
Citation:: BMC Microbiol, 2015, 15 (1), pp. 392 - ?
Issue Date:: 2015-12

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published VersionAdobe PDF (2.62 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Nolan, LM	en_US
dc.contributor.author	Cavaliere, R	en_US
dc.contributor.author	Turnbull, L https://orcid.org/0000-0002-9255-9033	en_US
dc.contributor.author	Whitchurch, CB	en_US
dc.date.issued	2015-12	en_US
dc.identifier.citation	BMC Microbiol, 2015, 15 (1), pp. 392 - ?	en_US
dc.identifier.uri	http://hdl.handle.net/10453/36246
dc.description.abstract	Pseudomonas aeruginosa is an opportunistic pathogen that exploits damaged epithelia to cause infection. Type IV pili (tfp) are polarly located filamentous structures which are the major adhesins for attachment of P. aeruginosa to epithelial cells. The extension and retraction of tfp powers a mode of surface translocation termed twitching motility that is involved in biofilm development and also mediates the active expansion of biofilms across surfaces. Extracellular adenosine triphosphate (eATP) is a key "danger" signalling molecule that is released by damaged epithelial cells to alert the immune system to the potential presence of pathogens. As P. aeruginosa has a propensity for infecting damaged epithelial tissues we have explored the influence of eATP on tfp biogenesis and twitching motility-mediated biofilm expansion by P. aeruginosa.	en_US
dc.language	eng	en_US
dc.relation.ispartof	BMC Microbiol	en_US
dc.relation.isbasedon	10.1186/s12866-015-0392-x	en_US
dc.subject.classification	Microbiology	en_US
dc.title	Extracellular ATP inhibits twitching motility-mediated biofilm expansion by Pseudomonas aeruginosa.	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	15	en_US
utslib.location.activity	England	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	07 Agricultural and Veterinary Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.declined	1970-01-01T00:00:00.0+1000
pubs.issue	1	en_US
pubs.volume	15	en_US

Abstract:

Pseudomonas aeruginosa is an opportunistic pathogen that exploits damaged epithelia to cause infection. Type IV pili (tfp) are polarly located filamentous structures which are the major adhesins for attachment of P. aeruginosa to epithelial cells. The extension and retraction of tfp powers a mode of surface translocation termed twitching motility that is involved in biofilm development and also mediates the active expansion of biofilms across surfaces. Extracellular adenosine triphosphate (eATP) is a key "danger" signalling molecule that is released by damaged epithelial cells to alert the immune system to the potential presence of pathogens. As P. aeruginosa has a propensity for infecting damaged epithelial tissues we have explored the influence of eATP on tfp biogenesis and twitching motility-mediated biofilm expansion by P. aeruginosa.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/36246