Nanoparticle-protein corona complexes govern the biological fates and functions of nanoparticles

Gunawan, C; Lim, M; Marquis, CP; Amal, R

Nanoparticle-protein corona complexes govern the biological fates and functions of nanoparticles

Gunawan, C

Lim, M Marquis, CP Amal, R

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Publication Type:: Journal Article
Citation:: Journal of Materials Chemistry B, 2014, 2 (15), pp. 2060 - 2083
Issue Date:: 2014-04-21

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Field	Value	Language
dc.contributor.author	Gunawan, C https://orcid.org/0000-0002-2957-1347	en_US
dc.contributor.author	Lim, M	en_US
dc.contributor.author	Marquis, CP	en_US
dc.contributor.author	Amal, R	en_US
dc.date.issued	2014-04-21	en_US
dc.identifier.citation	Journal of Materials Chemistry B, 2014, 2 (15), pp. 2060 - 2083	en_US
dc.identifier.issn	2050-7518	en_US
dc.identifier.uri	http://hdl.handle.net/10453/36308
dc.description.abstract	Upon contact with plasma or other protein-containing biological fluids, the surface of nanoparticles is immediately decorated with proteins forming a biologically active protein corona. The biological fates and functions of nanoparticles are determined by physiological responses toward these nanoparticle-protein corona complexes as the effective biological unit of nanoparticles. In this article, we review representative studies on the effects of particle physicochemical characteristics along with the protein profiles in the biological medium on the formation of protein corona and importantly, how the dynamic nature and protein fingerprints of the formed corona govern the biological responses toward nanoparticles. The biological effects arising from the presence of protein corona can be both beneficial and unfavourable to the biomedical applications of nanoparticles. The protein corona-cell interactions open up the feasibility of targeted delivery and cell-specific uptake of therapeutic nanoparticles and in other circumstances, engineering of nanoparticles as adjuvants for vaccine development as well as mitigation of the unintentional cytotoxic effects of nanoparticles. On the other hand, the protein corona-cell interactions could induce rapid clearance of nanoparticles from in vivo circulation as well as activating unwanted inflammatory responses. Taken together, the knowledge on the formation and biological effects of protein corona enables tailored tuning of the physicochemical characteristics of nanoparticles, unique to their intended biological activity. © 2014 the Partner Organisations.	en_US
dc.relation.ispartof	Journal of Materials Chemistry B	en_US
dc.relation.isbasedon	10.1039/c3tb21526a	en_US
dc.title	Nanoparticle-protein corona complexes govern the biological fates and functions of nanoparticles	en_US
dc.type	Journal Article
utslib.citation.volume	15	en_US
utslib.citation.volume	2	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	0303 Macromolecular and Materials Chemistry	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	15	en_US
pubs.publication-status	Published	en_US
pubs.volume	2	en_US

Abstract:

Upon contact with plasma or other protein-containing biological fluids, the surface of nanoparticles is immediately decorated with proteins forming a biologically active protein corona. The biological fates and functions of nanoparticles are determined by physiological responses toward these nanoparticle-protein corona complexes as the effective biological unit of nanoparticles. In this article, we review representative studies on the effects of particle physicochemical characteristics along with the protein profiles in the biological medium on the formation of protein corona and importantly, how the dynamic nature and protein fingerprints of the formed corona govern the biological responses toward nanoparticles. The biological effects arising from the presence of protein corona can be both beneficial and unfavourable to the biomedical applications of nanoparticles. The protein corona-cell interactions open up the feasibility of targeted delivery and cell-specific uptake of therapeutic nanoparticles and in other circumstances, engineering of nanoparticles as adjuvants for vaccine development as well as mitigation of the unintentional cytotoxic effects of nanoparticles. On the other hand, the protein corona-cell interactions could induce rapid clearance of nanoparticles from in vivo circulation as well as activating unwanted inflammatory responses. Taken together, the knowledge on the formation and biological effects of protein corona enables tailored tuning of the physicochemical characteristics of nanoparticles, unique to their intended biological activity. © 2014 the Partner Organisations.

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http://hdl.handle.net/10453/36308