Zinc oxide nanoparticles induce cell filamentation in escherichia coli

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Journal Article
Particle and Particle Systems Characterization, 2013, 30 (4), pp. 375 - 380
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Zinc oxide nanoparticles (ZnO NPs) induce morphological transformation of Escherichia coli from its native rod-shape of ≈2-4 μm to filamentous cells of 20-40 μm in length. The transient response can only be observed at up to 3.5 h proliferation, beyond which the cytotoxic effect is neutralized and the rod-shape is restored. The filamentation is part of the bacterium SOS response to the Trojan horse-type internalization of undissolved ZnO solids. In the absence of ZnO solids, no cell filamentation can be observed from the leached soluble zinc fraction or dissolved zinc salt. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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