Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions

McCarty, KM; Chen, YC; Quamruzzaman, Q; Rahman, M; Mahiuddin, G; Hsueh, YM; Su, L; Smith, T; Ryan, L; Christiani, DC

Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions

McCarty, KM Chen, YC Quamruzzaman, Q Rahman, M Mahiuddin, G Hsueh, YM Su, L Smith, T Ryan, L

Christiani, DC

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Publication Type:: Journal Article
Citation:: Environmental Health Perspectives, 2007, 115 (3), pp. 341 - 345
Issue Date:: 2007-03-01

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Field	Value	Language
dc.contributor.author	McCarty, KM	en_US
dc.contributor.author	Chen, YC	en_US
dc.contributor.author	Quamruzzaman, Q	en_US
dc.contributor.author	Rahman, M	en_US
dc.contributor.author	Mahiuddin, G	en_US
dc.contributor.author	Hsueh, YM	en_US
dc.contributor.author	Su, L	en_US
dc.contributor.author	Smith, T	en_US
dc.contributor.author	Ryan, L https://orcid.org/0000-0001-5957-2490	en_US
dc.contributor.author	Christiani, DC	en_US
dc.date.available	2006-12-20	en_US
dc.date.issued	2007-03-01	en_US
dc.identifier.citation	Environmental Health Perspectives, 2007, 115 (3), pp. 341 - 345	en_US
dc.identifier.issn	0091-6765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/36736
dc.description.abstract	Objective: We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. Methods: A case-control study of 600 cases and 600 controls that were frequency matched on age and sex was conducted in Pabna, Bangladesh, in 2001-2002. Individual well water, urine, and blood samples were collected. Water arsenic concentration was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary arsenic speciation was determined using high performance liquid chromatography hydride with generator atomic absorption spectrometry and ICP-MS. Genotyping was conducted using multiplex polymerase chain reaction and TaqMan. Results: A 10-fold increase in primary methylation ratio [monomethylarsonic acid (MMA)/(arsenite + arsenate) was associated with a 1.50-fold increased risk of skin lesions (multivariate odds ratio = 1.50; 95% confidence interval, 1.00-2.26). We observed significant interaction on the multiplicative scale between GSTT1 wildtype and secondary methylation ratio [dimethylarsinic acid/MMA; likelihood ratio test (LRT), p = 0.01]. No significant interactions were observed for GSTM1 or GSTP1 or for primary mathylation ratios. Conclusion: Our findings suggest that increasing primary methylation ratios are associated with an increase in risk of arsenic-related skin lesions. The interaction between GSTT1 wildtype and secondary methylation ratio modifies risk of skin lesions among arsenic-exposed individuals.	en_US
dc.relation.ispartof	Environmental Health Perspectives	en_US
dc.relation.isbasedon	10.1289/ehp.9152	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Nails	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Skin Diseases	en_US
dc.subject.mesh	Arsenicals	en_US
dc.subject.mesh	Arsenates	en_US
dc.subject.mesh	Arsenites	en_US
dc.subject.mesh	Arsenic	en_US
dc.subject.mesh	Cacodylic Acid	en_US
dc.subject.mesh	Glutathione Transferase	en_US
dc.subject.mesh	Water Pollutants, Chemical	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Water Supply	en_US
dc.subject.mesh	Methylation	en_US
dc.subject.mesh	Polymorphism, Genetic	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Bangladesh	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Glutathione S-Transferase pi	en_US
dc.title	Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	115	en_US
utslib.for	05 Environmental Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	115	en_US

Abstract:

Objective: We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. Methods: A case-control study of 600 cases and 600 controls that were frequency matched on age and sex was conducted in Pabna, Bangladesh, in 2001-2002. Individual well water, urine, and blood samples were collected. Water arsenic concentration was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary arsenic speciation was determined using high performance liquid chromatography hydride with generator atomic absorption spectrometry and ICP-MS. Genotyping was conducted using multiplex polymerase chain reaction and TaqMan. Results: A 10-fold increase in primary methylation ratio [monomethylarsonic acid (MMA)/(arsenite + arsenate) was associated with a 1.50-fold increased risk of skin lesions (multivariate odds ratio = 1.50; 95% confidence interval, 1.00-2.26). We observed significant interaction on the multiplicative scale between GSTT1 wildtype and secondary methylation ratio [dimethylarsinic acid/MMA; likelihood ratio test (LRT), p = 0.01]. No significant interactions were observed for GSTM1 or GSTP1 or for primary mathylation ratios. Conclusion: Our findings suggest that increasing primary methylation ratios are associated with an increase in risk of arsenic-related skin lesions. The interaction between GSTT1 wildtype and secondary methylation ratio modifies risk of skin lesions among arsenic-exposed individuals.

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