Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

Rashid, I; van Reyk, DM; Davies, MJ

Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

Rashid, I van Reyk, DM

Davies, MJ

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Publication Type:: Journal Article
Citation:: FEBS Letters, 2007, 581 (5), pp. 1067 - 1070
Issue Date:: 2007-03-06

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Field	Value	Language
dc.contributor.author	Rashid, I	en_US
dc.contributor.author	van Reyk, DM https://orcid.org/0000-0002-7768-8662	en_US
dc.contributor.author	Davies, MJ	en_US
dc.date.available	2007-01-25	en_US
dc.date.issued	2007-03-06	en_US
dc.identifier.citation	FEBS Letters, 2007, 581 (5), pp. 1067 - 1070	en_US
dc.identifier.issn	0014-5793	en_US
dc.identifier.uri	http://hdl.handle.net/10453/3775
dc.description.abstract	Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids β-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis. © 2007 Federation of European Biochemical Societies.	en_US
dc.relation.ispartof	FEBS Letters	en_US
dc.relation.isbasedon	10.1016/j.febslet.2007.01.082	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Macrophages	en_US
dc.subject.mesh	Foam Cells	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Cardiovascular Diseases	en_US
dc.subject.mesh	Diabetic Angiopathies	en_US
dc.subject.mesh	Lipoproteins, LDL	en_US
dc.subject.mesh	beta-Alanine	en_US
dc.subject.mesh	Histidine	en_US
dc.subject.mesh	Carnosine	en_US
dc.subject.mesh	Glycosylation	en_US
dc.subject.mesh	In Vitro Techniques	en_US
dc.title	Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	581	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	0603 Evolutionary Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	581	en_US

Abstract:

Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids β-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis. © 2007 Federation of European Biochemical Societies.

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http://hdl.handle.net/10453/3775