Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

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Journal Article
FEBS Letters, 2007, 581 (5), pp. 1067 - 1070
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Gycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can resultin the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosis, or its constituent amino acids beta-alanine and L-histidine, can inhibit the modification of LDL by glycolaldehyde when prsent at equimolar concentrations to the modifying agent,. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. This carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.
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