The application of terminomics for the identification of protein start sites and proteoforms in bacteria

Berry, IJ; Steele, JR; Padula, MP; Djordjevic, SP

The application of terminomics for the identification of protein start sites and proteoforms in bacteria

Berry, IJ

Steele, JR

Padula, MP

Djordjevic, SP

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Publication Type:: Journal Article
Citation:: Proteomics, 2016, 16 (2), pp. 257 - 272
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Berry, IJ https://orcid.org/0000-0002-0322-2595	en_US
dc.contributor.author	Steele, JR https://orcid.org/0000-0002-3070-9761	en_US
dc.contributor.author	Padula, MP https://orcid.org/0000-0002-8283-0643	en_US
dc.contributor.author	Djordjevic, SP https://orcid.org/0000-0001-9301-5372	en_US
dc.date.available	2015-09-30	en_US
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	Proteomics, 2016, 16 (2), pp. 257 - 272	en_US
dc.identifier.issn	1615-9853	en_US
dc.identifier.uri	http://hdl.handle.net/10453/37871
dc.description.abstract	© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Protein terminomics, or the study of amino acids sequences at the protein amino or carboxyl terminus has rapidly evolved as a proteomic discipline due to significant methodological improvements in the labelling and recovery of terminal peptides as well as the increased speed and sensitivity of current mass spectrometry instrumentation. The most significant beneficiaries of these developments include an increased awareness and understanding of complex proteolytic cascades that regulate key biological processes and in genome annotation. Most terminomics research to date has focused on gaining insight into important biological processes such as inflammation, wound healing and cancer. The application of terminomics to the study of important biological questions in prokaryotes is gaining traction. Here we review current applications and progress of terminomics in prokaryotes, discuss the significance of protease research in bacterial pathogenesis and protein maturation, and suggest novel applications of terminomics in the study of infectious disease.	en_US
dc.relation.ispartof	Proteomics	en_US
dc.relation.isbasedon	10.1002/pmic.201500319	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Bacteria	en_US
dc.subject.mesh	Protein Sorting Signals	en_US
dc.subject.mesh	Bacterial Proteins	en_US
dc.subject.mesh	Protein Isoforms	en_US
dc.subject.mesh	Sequence Analysis, Protein	en_US
dc.subject.mesh	Proteomics	en_US
dc.subject.mesh	Protein Processing, Post-Translational	en_US
dc.subject.mesh	Genome, Bacterial	en_US
dc.subject.mesh	Open Reading Frames	en_US
dc.subject.mesh	Transcription Initiation Site	en_US
dc.subject.mesh	Mass Spectrometry	en_US
dc.title	The application of terminomics for the identification of protein start sites and proteoforms in bacteria	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	16	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1107 Immunology	en_US
utslib.for	060109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics)	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	08 Information and Computing Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Provost
pubs.organisational-group	/University of Technology Sydney/Provost/Jumbunna
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	16	en_US

Abstract:

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Protein terminomics, or the study of amino acids sequences at the protein amino or carboxyl terminus has rapidly evolved as a proteomic discipline due to significant methodological improvements in the labelling and recovery of terminal peptides as well as the increased speed and sensitivity of current mass spectrometry instrumentation. The most significant beneficiaries of these developments include an increased awareness and understanding of complex proteolytic cascades that regulate key biological processes and in genome annotation. Most terminomics research to date has focused on gaining insight into important biological processes such as inflammation, wound healing and cancer. The application of terminomics to the study of important biological questions in prokaryotes is gaining traction. Here we review current applications and progress of terminomics in prokaryotes, discuss the significance of protease research in bacterial pathogenesis and protein maturation, and suggest novel applications of terminomics in the study of infectious disease.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/37871