Implications and emerging control strategies for ventilator-associated infections

Loo, CY; Lee, WH; Young, PM; Cavaliere, R; Whitchurch, CB; Rohanizadeh, R

Implications and emerging control strategies for ventilator-associated infections

Loo, CY Lee, WH Young, PM

Cavaliere, R

Whitchurch, CB

Rohanizadeh, R

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Publication Type:: Journal Article
Citation:: Expert Review of Anti-Infective Therapy, 2015, 13 (3), pp. 379 - 393
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Loo, CY	en_US
dc.contributor.author	Lee, WH	en_US
dc.contributor.author	Young, PM https://orcid.org/0000-0002-4357-7999	en_US
dc.contributor.author	Cavaliere, R https://orcid.org/0000-0002-4709-5081	en_US
dc.contributor.author	Whitchurch, CB https://orcid.org/0000-0003-2296-3791	en_US
dc.contributor.author	Rohanizadeh, R	en_US
dc.date.available	2020-05-25T19:08:01Z
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	Expert Review of Anti-Infective Therapy, 2015, 13 (3), pp. 379 - 393	en_US
dc.identifier.issn	1478-7210	en_US
dc.identifier.uri	http://hdl.handle.net/10453/37920
dc.description.abstract	© 2015 Informa UK, Ltd Ventilator-associated pneumonia (VAP) remains a major burden to the healthcare system and intubated patients in intensive care units. In fact, VAP is responsible for at least 50% of prescribed antibiotics to patients who need mechanical ventilation. One of the factors contributing to VAP pathogenesis is believed to be rapid colonization of biofilm-forming pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus on the surface of inserted endotracheal tubes. These biofilms serve as a protective environment for bacterial colonies and provide enhanced resistance towards many antibiotics. This review presents and discusses an overview of current strategies to inhibit the colonization and formation of biofilm on endotracheal tubes, including antibiotic treatment, surface modification and antimicrobial agent incorporation onto endotracheal tube materials.	en_US
dc.relation.ispartof	Expert Review of Anti-Infective Therapy	en_US
dc.relation.isbasedon	10.1586/14787210.2015.1007045	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Biofilms	en_US
dc.subject.mesh	Pseudomonas aeruginosa	en_US
dc.subject.mesh	Staphylococcus aureus	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Respiration, Artificial	en_US
dc.subject.mesh	Intubation, Intratracheal	en_US
dc.subject.mesh	Ventilators, Mechanical	en_US
dc.subject.mesh	Intensive Care Units	en_US
dc.subject.mesh	Pneumonia, Ventilator-Associated	en_US
dc.title	Implications and emerging control strategies for ventilator-associated infections	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	13	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

© 2015 Informa UK, Ltd Ventilator-associated pneumonia (VAP) remains a major burden to the healthcare system and intubated patients in intensive care units. In fact, VAP is responsible for at least 50% of prescribed antibiotics to patients who need mechanical ventilation. One of the factors contributing to VAP pathogenesis is believed to be rapid colonization of biofilm-forming pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus on the surface of inserted endotracheal tubes. These biofilms serve as a protective environment for bacterial colonies and provide enhanced resistance towards many antibiotics. This review presents and discusses an overview of current strategies to inhibit the colonization and formation of biofilm on endotracheal tubes, including antibiotic treatment, surface modification and antimicrobial agent incorporation onto endotracheal tube materials.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/37920