Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues

Roulis, E; Bachmann, NL; Myers, GSA; Huston, W; Summersgill, J; Hudson, A; Dreses-Werringloer, U; Polkinghorne, A; Timms, P

Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues

Roulis, E Bachmann, NL Myers, GSA

Huston, W

Summersgill, J Hudson, A Dreses-Werringloer, U Polkinghorne, A Timms, P

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Publication Type:: Journal Article
Citation:: Genomics, 2015, 106 (6), pp. 373 - 383
Issue Date:: 2015-12-01

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Field	Value	Language
dc.contributor.author	Roulis, E	en_US
dc.contributor.author	Bachmann, NL	en_US
dc.contributor.author	Myers, GSA https://orcid.org/0000-0002-4756-4810	en_US
dc.contributor.author	Huston, W https://orcid.org/0000-0002-0879-1287	en_US
dc.contributor.author	Summersgill, J	en_US
dc.contributor.author	Hudson, A	en_US
dc.contributor.author	Dreses-Werringloer, U	en_US
dc.contributor.author	Polkinghorne, A	en_US
dc.contributor.author	Timms, P	en_US
dc.date.available	2015-09-24	en_US
dc.date.issued	2015-12-01	en_US
dc.identifier.citation	Genomics, 2015, 106 (6), pp. 373 - 383	en_US
dc.identifier.issn	0888-7543	en_US
dc.identifier.uri	http://hdl.handle.net/10453/39721
dc.description.abstract	© 2015 Elsevier Inc. Chlamydia pneumoniae is an obligate intracellular bacterium implicated in a wide range of human diseases including atherosclerosis and Alzheimer's disease. Efforts to understand the relationships between C. pneumoniae detected in these diseases have been hindered by the availability of sequence data for non-respiratory strains. In this study, we sequenced the whole genomes for C. pneumoniae isolates from atherosclerosis and Alzheimer's disease, and compared these to previously published C. pneumoniae genomes. Phylogenetic analyses of these new C. pneumoniae strains indicate two sub-groups within human C. pneumoniae, and suggest that both recombination and mutation events have driven the evolution of human C. pneumoniae. Further fine-detailed analyses of these new C. pneumoniae sequences show several genetically variable loci. This suggests that similar strains of C. pneumoniae are found in the brain, lungs and cardiovascular system and that only minor genetic differences may contribute to the adaptation of particular strains in human disease.	en_US
dc.relation.ispartof	Genomics	en_US
dc.relation.isbasedon	10.1016/j.ygeno.2015.09.008	en_US
dc.subject.classification	Genetics & Heredity	en_US
dc.subject.mesh	Respiratory System	en_US
dc.subject.mesh	Heart	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Chlamydophila pneumoniae	en_US
dc.subject.mesh	Chlamydophila Infections	en_US
dc.subject.mesh	Alzheimer Disease	en_US
dc.subject.mesh	Sequence Analysis, DNA	en_US
dc.subject.mesh	Genomics	en_US
dc.subject.mesh	Adaptation, Physiological	en_US
dc.subject.mesh	Evolution, Molecular	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Species Specificity	en_US
dc.subject.mesh	Recombination, Genetic	en_US
dc.subject.mesh	Mutation	en_US
dc.subject.mesh	Polymorphism, Single Nucleotide	en_US
dc.subject.mesh	Genome, Bacterial	en_US
dc.subject.mesh	Atherosclerosis	en_US
dc.subject.mesh	Host-Pathogen Interactions	en_US
dc.title	Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	106	en_US
utslib.for	0806 Information Systems	en_US
utslib.for	0604 Genetics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	106	en_US

Abstract:

© 2015 Elsevier Inc. Chlamydia pneumoniae is an obligate intracellular bacterium implicated in a wide range of human diseases including atherosclerosis and Alzheimer's disease. Efforts to understand the relationships between C. pneumoniae detected in these diseases have been hindered by the availability of sequence data for non-respiratory strains. In this study, we sequenced the whole genomes for C. pneumoniae isolates from atherosclerosis and Alzheimer's disease, and compared these to previously published C. pneumoniae genomes. Phylogenetic analyses of these new C. pneumoniae strains indicate two sub-groups within human C. pneumoniae, and suggest that both recombination and mutation events have driven the evolution of human C. pneumoniae. Further fine-detailed analyses of these new C. pneumoniae sequences show several genetically variable loci. This suggests that similar strains of C. pneumoniae are found in the brain, lungs and cardiovascular system and that only minor genetic differences may contribute to the adaptation of particular strains in human disease.

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http://hdl.handle.net/10453/39721