Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
Paulsen, IT
Banerjei, L
Hyers, GSA
Nelson, KE
Seshadri, R
Read, TD
Fouts, DE
Eisen, JA
Gill, SR
Heidelberg, JF
Tettelin, H
Dodson, RJ
Umayam, L
Brinkac, L
Beanan, M
Daugherty, S
DeBoy, RT
Durkin, S
Kolonay, J
Madupu, R
Nelson, W
Vamathevan, J
Tran, B
Upton, J
Hansen, T
Shetty, J
Khouri, H
Utterback, T
Radune, D
Ketchum, KA
Dougherty, BA
Fraser, CM
- Publication Type:
- Journal Article
- Citation:
- Science, 2003, 299 (5615), pp. 2071 - 2074
- Issue Date:
- 2003-03-28
Closed Access
Filename | Description | Size | |||
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Paulsen, IT | en_US |
dc.contributor.author | Banerjei, L | en_US |
dc.contributor.author |
Hyers, GSA |
en_US |
dc.contributor.author | Nelson, KE | en_US |
dc.contributor.author | Seshadri, R | en_US |
dc.contributor.author | Read, TD | en_US |
dc.contributor.author | Fouts, DE | en_US |
dc.contributor.author | Eisen, JA | en_US |
dc.contributor.author | Gill, SR | en_US |
dc.contributor.author | Heidelberg, JF | en_US |
dc.contributor.author | Tettelin, H | en_US |
dc.contributor.author | Dodson, RJ | en_US |
dc.contributor.author | Umayam, L | en_US |
dc.contributor.author | Brinkac, L | en_US |
dc.contributor.author | Beanan, M | en_US |
dc.contributor.author | Daugherty, S | en_US |
dc.contributor.author | DeBoy, RT | en_US |
dc.contributor.author | Durkin, S | en_US |
dc.contributor.author | Kolonay, J | en_US |
dc.contributor.author | Madupu, R | en_US |
dc.contributor.author | Nelson, W | en_US |
dc.contributor.author | Vamathevan, J | en_US |
dc.contributor.author | Tran, B | en_US |
dc.contributor.author | Upton, J | en_US |
dc.contributor.author | Hansen, T | en_US |
dc.contributor.author | Shetty, J | en_US |
dc.contributor.author | Khouri, H | en_US |
dc.contributor.author | Utterback, T | en_US |
dc.contributor.author | Radune, D | en_US |
dc.contributor.author | Ketchum, KA | en_US |
dc.contributor.author | Dougherty, BA | en_US |
dc.contributor.author | Fraser, CM | en_US |
dc.date.issued | 2003-03-28 | en_US |
dc.identifier.citation | Science, 2003, 299 (5615), pp. 2071 - 2074 | en_US |
dc.identifier.issn | 0036-8075 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/39769 | |
dc.description.abstract | The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci. | en_US |
dc.relation.ispartof | Science | en_US |
dc.relation.isbasedon | 10.1126/science.1080613 | en_US |
dc.subject.classification | General Science & Technology | en_US |
dc.subject.mesh | Digestive System | en_US |
dc.subject.mesh | Chromosomes, Bacterial | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Enterococcus faecalis | en_US |
dc.subject.mesh | Gram-Positive Bacterial Infections | en_US |
dc.subject.mesh | Bacterial Proteins | en_US |
dc.subject.mesh | Adhesins, Bacterial | en_US |
dc.subject.mesh | Carrier Proteins | en_US |
dc.subject.mesh | DNA Transposable Elements | en_US |
dc.subject.mesh | Virulence Factors | en_US |
dc.subject.mesh | Sequence Analysis, DNA | en_US |
dc.subject.mesh | Bacterial Adhesion | en_US |
dc.subject.mesh | Drug Resistance, Multiple, Bacterial | en_US |
dc.subject.mesh | Vancomycin Resistance | en_US |
dc.subject.mesh | Lysogeny | en_US |
dc.subject.mesh | Virulence | en_US |
dc.subject.mesh | Conjugation, Genetic | en_US |
dc.subject.mesh | Gene Transfer, Horizontal | en_US |
dc.subject.mesh | Interspersed Repetitive Sequences | en_US |
dc.subject.mesh | Conserved Sequence | en_US |
dc.subject.mesh | Synteny | en_US |
dc.subject.mesh | Oxidative Stress | en_US |
dc.subject.mesh | Genome, Bacterial | en_US |
dc.subject.mesh | Open Reading Frames | en_US |
dc.subject.mesh | Plasmids | en_US |
dc.subject.mesh | Biological Evolution | en_US |
dc.title | Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 5615 | en_US |
utslib.citation.volume | 299 | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation | |
utslib.copyright.status | closed_access | |
pubs.issue | 5615 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 299 | en_US |
Abstract:
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
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