Tn6026 and Tn6029 are found in complex resistance regions mobilised by diverse plasmids and chromosomal islands in multiple antibiotic resistant Enterobacteriaceae

Reid, CJ; Chowdhury, PR; Djordjevic, SP

Tn6026 and Tn6029 are found in complex resistance regions mobilised by diverse plasmids and chromosomal islands in multiple antibiotic resistant Enterobacteriaceae

Reid, CJ

Chowdhury, PR

Djordjevic, SP

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Publication Type:: Journal Article
Citation:: Plasmid, 2015, 80 pp. 127 - 137
Issue Date:: 2015-07-01

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Field	Value	Language
dc.contributor.author	Reid, CJ https://orcid.org/0000-0001-6872-330X	en_US
dc.contributor.author	Chowdhury, PR https://orcid.org/0000-0003-4352-603X	en_US
dc.contributor.author	Djordjevic, SP https://orcid.org/0000-0001-9301-5372	en_US
dc.date.available	2020-05-25T19:27:30Z
dc.date.issued	2015-07-01	en_US
dc.identifier.citation	Plasmid, 2015, 80 pp. 127 - 137	en_US
dc.identifier.issn	0147-619X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/43415
dc.description.abstract	© 2015. Transposons flanked by direct copies of IS. 26 are important contributors to the evolution of multiple antibiotic resistance. Tn. 6029 and Tn. 6026 are examples of composite transposons that have become widely disseminated on small and large plasmids with different incompatibility markers in pathogenic and commensal Escherichia coli and various serovars of Salmonella enterica. Some of the plasmids that harbour these transposons also carry combinations of virulence genes. Recently, Tn. 6029 and Tn. 6026 and derivatives thereof have been found on chromosomal islands in both established and recently emerged pathogens. While Tn. 6029 and Tn. 6026 carry genes encoding resistance to older generation antibiotics, they also provide a scaffold for the introduction of genes encoding resistance to a wide variety of clinically relevant antibiotics that are mobilised by IS. 26. As a consequence, Tn. 6029 and Tn. 6026 or variants are likely to increasingly feature in complex resistance regions in multiple antibiotic resistant Enterobacteriaceae that threaten the health of humans and food production animals.	en_US
dc.relation.ispartof	Plasmid	en_US
dc.relation.isbasedon	10.1016/j.plasmid.2015.04.005	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Chromosomes, Bacterial	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Enterobacteriaceae	en_US
dc.subject.mesh	DNA Transposable Elements	en_US
dc.subject.mesh	Drug Resistance, Multiple, Bacterial	en_US
dc.subject.mesh	Virulence	en_US
dc.subject.mesh	Genes, Bacterial	en_US
dc.subject.mesh	Plasmids	en_US
dc.title	Tn6026 and Tn6029 are found in complex resistance regions mobilised by diverse plasmids and chromosomal islands in multiple antibiotic resistant Enterobacteriaceae	en_US
dc.type	Journal Article
utslib.citation.volume	80	en_US
utslib.for	0604 Genetics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	80	en_US

Abstract:

© 2015. Transposons flanked by direct copies of IS. 26 are important contributors to the evolution of multiple antibiotic resistance. Tn. 6029 and Tn. 6026 are examples of composite transposons that have become widely disseminated on small and large plasmids with different incompatibility markers in pathogenic and commensal Escherichia coli and various serovars of Salmonella enterica. Some of the plasmids that harbour these transposons also carry combinations of virulence genes. Recently, Tn. 6029 and Tn. 6026 and derivatives thereof have been found on chromosomal islands in both established and recently emerged pathogens. While Tn. 6029 and Tn. 6026 carry genes encoding resistance to older generation antibiotics, they also provide a scaffold for the introduction of genes encoding resistance to a wide variety of clinically relevant antibiotics that are mobilised by IS. 26. As a consequence, Tn. 6029 and Tn. 6026 or variants are likely to increasingly feature in complex resistance regions in multiple antibiotic resistant Enterobacteriaceae that threaten the health of humans and food production animals.

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http://hdl.handle.net/10453/41083