Association of expired nitric oxide with occupational particulate exposure

Kim, JY; Wand, MP; Hauser, R; Mukherjee, S; Herrick, RF; Christiani, DC

Association of expired nitric oxide with occupational particulate exposure

Kim, JY Wand, MP

Hauser, R Mukherjee, S Herrick, RF Christiani, DC

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Publication Type:: Journal Article
Citation:: Environmental Health Perspectives, 2003, 111 (5), pp. 676 - 680
Issue Date:: 2003-05-01

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Field	Value	Language
dc.contributor.author	Kim, JY	en_US
dc.contributor.author	Wand, MP https://orcid.org/0000-0003-2555-896X	en_US
dc.contributor.author	Hauser, R	en_US
dc.contributor.author	Mukherjee, S	en_US
dc.contributor.author	Herrick, RF	en_US
dc.contributor.author	Christiani, DC	en_US
dc.date.issued	2003-05-01	en_US
dc.identifier.citation	Environmental Health Perspectives, 2003, 111 (5), pp. 676 - 680	en_US
dc.identifier.issn	0091-6765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41307
dc.description.abstract	Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (FENO) and exposure to particulate matter with an aerodynamic mass median diameter of ≤ 2.5 μm (PM2.5) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20 or 2000 (n = 14). The Wilcoxon median baseline FENO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM2.5 8-hr time-weighted average was 0.56 mg/m3 (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m3 (95% CI: 0.65, 1.07) in 2000. FENO levels during the work week were significantly lower than baseline FENO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed FENO and the previous workday's PM2.5 concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m3 incremental increase in PM2.5 exposure, log FENO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM2.5 exposure and FENO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in FENO in a survey of workers with limited respirator usage.	en_US
dc.relation.ispartof	Environmental Health Perspectives	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Respiratory System	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Nitric Oxide	en_US
dc.subject.mesh	Metals	en_US
dc.subject.mesh	Free Radical Scavengers	en_US
dc.subject.mesh	Occupational Exposure	en_US
dc.subject.mesh	Particle Size	en_US
dc.subject.mesh	Metallurgy	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Male	en_US
dc.title	Association of expired nitric oxide with occupational particulate exposure	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	111	en_US
utslib.for	05 Environmental Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	111	en_US

Abstract:

Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (FENO) and exposure to particulate matter with an aerodynamic mass median diameter of ≤ 2.5 μm (PM2.5) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20 or 2000 (n = 14). The Wilcoxon median baseline FENO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM2.5 8-hr time-weighted average was 0.56 mg/m3 (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m3 (95% CI: 0.65, 1.07) in 2000. FENO levels during the work week were significantly lower than baseline FENO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed FENO and the previous workday's PM2.5 concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m3 incremental increase in PM2.5 exposure, log FENO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM2.5 exposure and FENO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in FENO in a survey of workers with limited respirator usage.

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http://hdl.handle.net/10453/41307