Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma

Tovey, ER; Stelzer-Braid, S; Toelle, BG; Oliver, BG; Reddel, HK; Willenborg, CM; Belessis, Y; Garden, FL; Jaffe, A; Strachan, R; Eyles, D; Rawlinson, WD; Marks, GB

Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma

Tovey, ER Stelzer-Braid, S

Toelle, BG Oliver, BG

Reddel, HK Willenborg, CM Belessis, Y Garden, FL Jaffe, A Strachan, R Eyles, D Rawlinson, WD Marks, GB

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Publication Type:: Journal Article
Citation:: Journal of Allergy and Clinical Immunology, 2015, 135 (3), pp. 663 - 669.e12
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Tovey, ER	en_US
dc.contributor.author	Stelzer-Braid, S https://orcid.org/0000-0001-6037-9305	en_US
dc.contributor.author	Toelle, BG	en_US
dc.contributor.author	Oliver, BG https://orcid.org/0000-0002-7122-9262	en_US
dc.contributor.author	Reddel, HK	en_US
dc.contributor.author	Willenborg, CM	en_US
dc.contributor.author	Belessis, Y	en_US
dc.contributor.author	Garden, FL	en_US
dc.contributor.author	Jaffe, A	en_US
dc.contributor.author	Strachan, R	en_US
dc.contributor.author	Eyles, D	en_US
dc.contributor.author	Rawlinson, WD	en_US
dc.contributor.author	Marks, GB	en_US
dc.date.available	2014-10-14	en_US
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	Journal of Allergy and Clinical Immunology, 2015, 135 (3), pp. 663 - 669.e12	en_US
dc.identifier.issn	0091-6749	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41767
dc.description.abstract	© 2014 American Academy of Allergy, Asthma & Immunology. Background Viruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear.Objective We sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children.Methods Sixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed.Results Human rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P =.0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P <.0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms.Conclusion The detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms.	en_US
dc.relation.ispartof	Journal of Allergy and Clinical Immunology	en_US
dc.relation.isbasedon	10.1016/j.jaci.2014.10.020	en_US
dc.subject.classification	Allergy	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Rhinovirus	en_US
dc.subject.mesh	Picornaviridae Infections	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Cough	en_US
dc.subject.mesh	Respiratory Sounds	en_US
dc.subject.mesh	Adrenal Cortex Hormones	en_US
dc.subject.mesh	Vitamin D	en_US
dc.subject.mesh	Anti-Asthmatic Agents	en_US
dc.subject.mesh	Antigens, Dermatophagoides	en_US
dc.subject.mesh	Respiratory Function Tests	en_US
dc.subject.mesh	Regression Analysis	en_US
dc.subject.mesh	Genotype	en_US
dc.subject.mesh	Child	en_US
dc.subject.mesh	Child, Preschool	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	135	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	135	en_US

Abstract:

© 2014 American Academy of Allergy, Asthma & Immunology. Background Viruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear.Objective We sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children.Methods Sixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed.Results Human rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P =.0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P <.0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms.Conclusion The detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms.

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http://hdl.handle.net/10453/41767