You are what you secrete: extracellular proteins and virulence in Cryptococcus

Campbell, LT; Padula, MP; Harry, E; Carter, DA

You are what you secrete: extracellular proteins and virulence in Cryptococcus

Campbell, LT Padula, MP

Harry, E

Carter, DA

Permalink

Publisher:: CSIRO Publishing
Publication Type:: Journal Article
Citation:: Microbiology Australia, 2015, 36 (2), pp. 93 - 95
Issue Date:: 2015

Closed Access

	Filename	Description	Size
	MA15030.pdf	Accepted Manuscript Version	805.12 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Campbell, LT	en_US
dc.contributor.author	Padula, MP https://orcid.org/0000-0002-8283-0643	en_US
dc.contributor.author	Harry, E https://orcid.org/0000-0003-0858-9473	en_US
dc.contributor.author	Carter, DA	en_US
dc.date.issued	2015	en_US
dc.identifier.citation	Microbiology Australia, 2015, 36 (2), pp. 93 - 95	en_US
dc.identifier.issn	1324-4272	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41946
dc.description.abstract	Fungal organisms secrete a wide range of biomolecules, including degradative enzymes that are essential for nutrition, toxins, effectors and secondary compounds that modulate interactions with host animals and plants, and a variety of signaling and stress-related proteins1 . As these are likely to be key determinants of virulence and may also be useful diagnostic and therapeutic targets, we investigated the secretome of different strains of the fungal pathogen Cryptococcus. Virulent strains secreted predominantly hydrolytic and proteolytic enzymes, while the least virulent strain secreted a range of additional non-degradative proteins including many that lacked secretion signals, some that appear to be ‘moonlighting’, and a number that are known to be allergenic. It appears that in Cryptococcus, the secretome may influence virulence both through the presence of harmful enzymes and through the absence of proteins that alert the host defence mechanisms.	en_US
dc.publisher	CSIRO Publishing	en_US
dc.relation.ispartof	Microbiology Australia	en_US
dc.relation.isbasedon	10.1071/MA15030	en_US
dc.title	You are what you secrete: extracellular proteins and virulence in Cryptococcus	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	36	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0605 Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.consider-herdc	true	en_US
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	36	en_US

Abstract:

Fungal organisms secrete a wide range of biomolecules, including degradative enzymes that are essential for nutrition, toxins, effectors and secondary compounds that modulate interactions with host animals and plants, and a variety of signaling and stress-related proteins1 . As these are likely to be key determinants of virulence and may also be useful diagnostic and therapeutic targets, we investigated the secretome of different strains of the fungal pathogen Cryptococcus. Virulent strains secreted predominantly hydrolytic and proteolytic enzymes, while the least virulent strain secreted a range of additional non-degradative proteins including many that lacked secretion signals, some that appear to be ‘moonlighting’, and a number that are known to be allergenic. It appears that in Cryptococcus, the secretome may influence virulence both through the presence of harmful enzymes and through the absence of proteins that alert the host defence mechanisms.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/41946